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Naphazoline is a decongestant used to relieve redness, puffiness, and itchy/watering eyes due to colds, allergies, or eye irritations (smog, swimming, or wearing contact lenses). It is known as a sympathomimetic (alpha receptor agonist) that works in the eye to decrease congestion. Some brands of naphazoline eye drops also contain other ingredients. Lubricants (such as glycerin, hypromellose, or polyethylene glycol 300) help protect the eyes from more irritation. Zinc sulfate, an astringent, helps reduce redness and irritation.