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Aveeno Daily Moisturizing Lotion is a topical skin protectant primarily composed of dimethicone, which forms a protective barrier on the skin to prevent moisture loss. When applied externally as directed, it is not absorbed into the bloodstream, making systemic drug interactions unlikely. Therefore, there are no known significant interactions between this lotion and other medications.

However, it's important to use the lotion only on intact skin. Avoid applying it to deep or puncture wounds, animal bites, or serious burns. If your skin condition worsens or does not improve within seven days, discontinue use and consult a healthcare professional. (fda.report)

While adverse reactions are rare, some individuals may experience mild side effects such as burning, stinging, redness, or irritation at the application site. If these effects persist or worsen, seek medical advice promptly.

In summary, Aveeno Daily Moisturizing Lotion is generally safe for external use with minimal risk of drug interactions. Always follow the product's instructions and consult a healthcare provider if you have concerns about its use, especially if you have underlying skin conditions or are using other topical treatments.