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This document outlines essential safety and warning information regarding the use of the medication benznidazole. Please review these details thoroughly and consult your healthcare provider if you have any questions or concerns.

• Genetic Material Damage: Benznidazole has the potential to cause damage to DNA. While the implications for human health, including cancer risk, remain unclear, similar drugs have caused cancer in animal studies. Discuss any concerns with your healthcare provider.

• Risks During Pregnancy: In animal studies, benznidazole has been shown to harm unborn babies. Women who can become pregnant should have a pregnancy test before starting treatment and use effective contraception during therapy and for five days after stopping the medication. It is crucial to inform your provider if you are currently pregnant.

• Severe Skin Reactions: This medication may lead to serious and potentially life-threatening allergic skin reactions within the first 10 days of treatment. Symptoms may include fever, chills, eye irritation, painful swallowing, and extensive rash, blisters, or peeling skin. Discontinue use and seek immediate medical attention if these occur.

• Nerve Issues: Benznidazole can cause nerve-related problems, presenting as numbness, tingling, shooting pains, headaches, or dizziness. These symptoms can arise at any point during treatment but are more common with prolonged use. Notify your healthcare provider if you experience these symptoms; discontinuation of the drug may be necessary.

• Blood Cell Concerns: Though uncommon, benznidazole may lead to low counts of red and white blood cells and platelets, increasing the risk of infection, fatigue, and easy bruising. These effects are reversible upon cessation of the drug. If you have a history of blood disorders or use other medications affecting blood cell counts, your provider will likely monitor your blood levels closely. Report symptoms such as fatigue, dizziness, headaches, pallor, fever, or chills immediately.

Contraindications: Benznidazole should not be used under the following circumstances, as it may pose significant health risks:

• Recent use of disulfiram (Antabuse) within the past two weeks.
• Presence of Cockayne syndrome.

Always discuss your medical history and current medications with your healthcare provider to ensure the safe use of benznidazole.

Common side effects:

• dizziness
• headache
• abdominal pain
• nausea
• vomiting
• diarrhea
• decreased appetite
• weight loss
• rash
• sores on the skin

Serious side effects:

• numbness or tingling in the arms or legs
• easy bruising or bleeding
• unusual tiredness
• allergic reaction
• persistent fever
• new or worsening lymph node swelling
• severe rash
• itching
• swelling (particularly of the face, tongue, or throat)
• severe dizziness
• breathing difficulties

Interactions with high risk of serious adverse effects and should be avoided:

• Disulfiram