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This medication contains acetaminophen, and it's important to be aware of potential risks and necessary precautions when using it. Here are key safety and warning details you should consider:

• Liver Health: Excessive intake of acetaminophen can lead to severe, potentially fatal liver damage. Adult users should not exceed 4,000 milligrams (4 grams) per day. Those with liver conditions or children should consult with a healthcare provider to determine a safe dose. Avoid using other medications containing acetaminophen without medical advice, as it is often found in both prescription and over-the-counter drugs for pain, fever, and colds. Always check medication labels and consult a pharmacist if unsure. Immediate medical assistance is crucial in case of overdose, characterized by symptoms such as nausea, vomiting, loss of appetite, sweating, abdominal pain, fatigue, yellowing of the skin or eyes, and dark urine. Additionally, combining daily alcohol use with acetaminophen can lead to liver damage and should be avoided.

• Cognitive Effects: Fioricet, a medication containing acetaminophen, can cause significant drowsiness and impair concentration. Avoid alcohol and other medications that induce drowsiness or cognitive impairment, such as certain pain relievers and antidepressants, as they can enhance these effects. Assess how Fioricet affects you before engaging in tasks requiring alertness, like driving. If excessive drowsiness occurs, consult your healthcare provider. Risks are higher for individuals over 65, those consuming alcohol, or using other sedative medications.

• Allergic Reactions and Skin Issues: Although rare, acetaminophen can cause severe allergic reactions and skin conditions. Do not use Fioricet if you have a known allergy to acetaminophen. Seek emergency medical attention if you experience signs of an allergic reaction, such as facial swelling, breathing difficulties, hives, or vomiting. If skin reactions occur, such as redness, peeling, painful rashes, or blisters, discontinue use and visit an emergency facility immediately. Those with a history of serious skin reactions or acetaminophen allergies should exercise particular caution.

• Dependency and Withdrawal: Fioricet contains butalbital, a substance that can lead to dependency. Misuse can result in addiction, accidental overdose, or death, as well as withdrawal symptoms if discontinued abruptly. To minimize these risks, adhere strictly to prescribed doses and duration. Avoid prolonged use or increasing doses without medical guidance.

• Contraindications: Fioricet should not be used by individuals with porphyria, a condition affecting skin and nerves. Consult your healthcare provider if this or any other contraindication applies to you.

Common side effects:

• Drowsiness
• Lightheadedness
• Dizziness
• Nausea
• Vomiting
• Stomach pain
• Constipation
• Dry mouth
• Increased need to urinate
• Slight tremor
• Trouble sleeping

Serious side effects:

• Mental or mood changes
• Fainting
• Seizures
• Fast or irregular heartbeat
• Allergic reactions
• Rash
• Itching
• Swelling (particularly of the face, tongue, or throat)
• Severe dizziness
• Trouble breathing
• Overdose symptoms
• Extreme sleepiness
• Slowed breathing
• Nausea (overdose symptom)
• Vomiting (overdose symptom)
• Sweating
• Confusion
• Withdrawal symptoms
• Restlessness
• Shakiness

Interactions with high risk of serious adverse effects and should be avoided:

• Riociguat
• Viloxazine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Darunavir
• Sodium Oxybate
• Isoniazid
• Ketoconazole
• Lithium
• Phenothiazines (e.g., chlorpromazine)
• Alfentanil
• Alprazolam
• Amobarbital
• Anisindione
• Aprobarbital
• Butabarbital
• Calcium Oxybate
• Capmatinib
• Carisoprodol
• Chloral Hydrate
• Chlordiazepoxide
• Chlorzoxazone
• Clarithromycin
• Clonazepam
• Clorazepate
• Dantrolene
• Diazepam
• Dicumarol
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Esketamine
• Estazolam
• Ethchlorvynol
• Etonogestrel
• Flunitrazepam
• Flurazepam
• Givosiran
• Halazepam
• Imatinib
• Iobenguane I 131
• Ketazolam
• Lorazepam
• Lormetazepam
• Magnesium Oxybate
• Medazepam
• Mephenesin
• Mephobarbital
• Meprobamate
• Metaxalone
• Methocarbamol
• Methohexital
• Midazolam
• Nifedipine
• Nitrazepam
• Oxazepam
• Peginterferon Alfa-2b
• Pentobarbital
• Phenindione
• Phenobarbital
• Phenprocoumon
• Piperaquine
• Pixantrone
• Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate
• Potassium Oxybate
• Prazepam
• Primidone
• Quazepam
• Secobarbital
• Temazepam
• Thiopental
• Trazodone
• Triazolam
• Ulipristal

Interactions with low risk that usually do not require a change in therapy:

• Doxycycline
• Estrogen
• Felodipine
• Lonafarnib
• Quinidine
• Rilpivirine
• Tamoxifen
• Theophylline
• Voriconazole
• Warfarin
• Metoprolol
• Prednisone
• Acenocoumarol
• Cannabis
• Carbamazepine
• Fosphenytoin
• Lixisenatide
• Ospemifene
• Phenytoin
• Zidovudine