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When using this medication, it is crucial to be aware of potential interactions and precautions to ensure safe and effective use. Below are important considerations:

• Drug Interactions: Some medications can interact with this drug, including digoxin and phosphate binders. Additionally, calcium can reduce the absorption of certain medications such as tetracycline antibiotics (e.g., doxycycline, minocycline), bisphosphonates (e.g., alendronate), estramustine, levothyroxine, and quinolone antibiotics (e.g., ciprofloxacin, levofloxacin). Certain medications such as bile acid sequestrants (e.g., cholestyramine, colestipol), mineral oil, and orlistat can decrease the absorption of vitamin D. To avoid these interactions, space out the doses of these medications as far apart as possible from your calcium/vitamin D doses. Consult your doctor or pharmacist for guidance on the appropriate timing between doses and to help establish a suitable dosing schedule.

• Product Labels: Carefully check the labels of all prescription and non-prescription products, including herbal supplements, antacids, laxatives, and vitamins, as they may contain calcium, phosphate, or vitamin D. Seek advice from your pharmacist on the safe use of these products.

• Similar Medications: Vitamin D is similar to calcitriol. Avoid using medications that contain calcitriol while taking vitamin D to prevent excessive intake.

• Laboratory Tests: This medication may interfere with certain laboratory tests, such as cholesterol tests, leading to inaccurate results. Ensure that laboratory personnel and all of your healthcare providers are aware that you are using this product.

By following these guidelines and consulting with healthcare professionals when needed, you can help manage potential interactions and use this medication safely.

Common side effects:

• Constipation
• Stomach upset

Less common but important to monitor:

• Nausea
• Vomiting
• Loss of appetite
• Unusual weight loss
• Changes in mental or mood conditions
• Altered urine output
• Bone or muscle pain
• Headache
• Increased thirst and urination
• Feelings of weakness or tiredness
• Rapid or pounding heartbeat

Serious side effects:

• Serious allergic reaction (rash, itching or swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Calcitriol

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Digoxin
• Phosphate binders
• Tetracycline antibiotics (e.g., doxycycline, Minocycline)
• Bisphosphonates (e.g., Alendronate)
• Estramustine
• Levothyroxine
• Quinolone antibiotics (e.g., Ciprofloxacin, Levofloxacin)
• Bile acid sequestrants (e.g., Cholestyramine, Colestipol)
• Orlistat

Interactions with low risk that usually do not require a change in therapy:

• Mineral Oil