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The following safety information highlights important risks and precautions associated with the use of cefepime (Maxipime). Please read thoroughly and discuss any concerns with your healthcare provider.

• Allergic Reactions: Be aware of potential allergic reactions to cefepime, which can be severe and include facial swelling, shock, and anaphylaxis. If you have a known allergy to penicillins or other cephalosporin antibiotics, inform your healthcare provider. Seek immediate medical attention if you experience hives, rash, swelling of the lips or tongue, or breathing difficulties after using this medication.

• Nervous System Side Effects: Although uncommon, some individuals have experienced serious nervous system effects such as hallucinations, seizures, involuntary movements, speech difficulties, and confusion while on cefepime. These effects are more likely in individuals with kidney problems who do not have their dosage adjusted appropriately. If any of these symptoms occur, contact emergency services or a healthcare professional immediately. Typically, these effects resolve after discontinuing the medication.

• Diarrhea from Clostridioides difficile Infection: Cefepime can increase the risk of a C. difficile infection, a serious condition that can lead to life-threatening diarrhea. Unlike regular antibiotic-associated diarrhea, C. diff infection can cause a rapid heart rate, foul-smelling diarrhea, fever, nausea, frequent and bloody stools. If these symptoms arise, seek medical assistance promptly for testing and treatment.

• Development of Drug-Resistant Bacteria: Ensure you follow your healthcare provider’s instructions on the duration and purpose of cefepime treatment. Misuse, such as using the drug for unapproved conditions or incorrect durations, can lead to the development of drug-resistant bacteria, potentially resulting in severe and hard-to-treat infections.

Contraindications: Do not use cefepime if you have a known allergy to penicillins or cephalosporin antibiotics, as this poses serious health risks. Always consult your healthcare provider before starting this medication if you are affected by these conditions.

Common side effects:

• swelling at the injection site
• redness at the injection site
• pain at the injection site
• rash
• itching
• hives
• nausea
• diarrhea
• headache
• fever

Serious side effects:

• serious allergic reactions
• seizures
• hallucinations
• uncontrollable movements
• confusion
• speech difficulties
• severe intestinal condition caused by C. difficile
• oral thrush
• new yeast infection
• signs of kidney problems
• signs of liver problems

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Cholera Vaccine, Live
• Warfarin