HomeConditionsCentral Precocious Puberty

Central Precocious Puberty

Central Precocious Puberty (CPP) is a condition where children start puberty earlier than usual. It can be caused by genetic, environmental, and hormonal factors. Symptoms include early development of secondary sexual characteristics. Diagnosis involves medical evaluation and hormone level testing. Treatment aims to delay puberty using medication. Early detection and proper treatment can lead to positive outcomes for affected children.

Best medications for Central Precocious Puberty

Drug NameClassRouteStandard DosagePrice
SynarelGonadotropin Releasing Hormone Agonists2 MG/MLfrom$3020.25
TriptodurGonadotropin Releasing Hormone AgonistsIntramuscular22.5 MGfrom$618608.83
Supprelin LAGonadotropin Releasing Hormone AgonistsSubcutaneous50 MGfrom$1474726.92

Central Precocious Puberty


Central Precocious Puberty (CPP) is a condition that affects children, causing them to start puberty earlier than usual. In CPP, the onset of puberty occurs before the age of 8 in girls and before the age of 9 in boys. This condition is different from the normal variation in the timing of pubertal development and requires medical intervention. The early activation of the hypothalamic-pituitary-gonadal axis, the hormonal system responsible for puberty, causes the premature release of reproductive hormones and sexual development.


The exact cause of CPP is often unknown, but it is thought to be influenced by a combination of genetic, environmental, and hormonal factors. In some cases, CPP may be idiopathic, meaning there is no identifiable cause. However, certain conditions such as brain tumors, infections, and structural abnormalities of the brain may also lead to the early activation of puberty. Additionally, there is evidence to suggest that obesity may contribute to the development of CPP.


The primary symptom of CPP is the early development of secondary sexual characteristics. Girls may experience breast development, growth of pubic hair, and onset of menstruation, while boys may experience growth of facial and pubic hair, deepening of the voice, and an increase in muscle mass. Other symptoms may include a rapid growth spurt, acne, body odor, and emotional changes.


To diagnose CPP, a thorough medical evaluation is necessary. This typically includes a detailed medical history, physical examination, and laboratory tests to measure hormone levels. X-rays of the hand and wrist may also be employed to determine bone age, which can help determine if puberty is occurring too early in relation to chronological age.


The goal of treating CPP is to delay the progression of puberty and ensure that the child reaches a more appropriate age for the onset of sexual development. This can be achieved through the use of medications known as gonadotropin-releasing hormone (GnRH) analogs. GnRH analogs work by decreasing the release of reproductive hormones, thereby slowing down puberty. Treatment is typically continued until the age at which puberty would naturally begin.


With early detection and appropriate treatment, the outlook for children with CPP is generally positive. Delaying the onset of puberty allows for physical and emotional maturation to occur at a more appropriate age. Regular monitoring, follow-up appointments, and support from healthcare professionals are essential in managing the condition effectively and ensuring optimal outcomes. In conclusion, Central Precocious Puberty is a condition where children experience the early onset of puberty. It requires medical attention to delay the progression of sexual development. With proper diagnosis and treatment, affected children can have a more normal adolescence and an improved quality of life. If you suspect your child may be experiencing early puberty, it is important to consult with a healthcare professional for appropriate evaluation and management.