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Peptic Ulcer Disease

Peptic Ulcer Disease (PUD) is a chronic condition characterized by the formation of open sores or ulcers in the stomach and duodenum. It is primarily caused by Helicobacter pylori infection and the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Common symptoms include abdominal pain, nausea, and weight loss. Diagnosing PUD involves various tests like endoscopy and biopsy. Treatment includes medications, lifestyle modifications, and eradicating H. pylori. Prevention involves proper medication use and maintaining a healthy lifestyle.

Best medications for Peptic Ulcer Disease

Drug NameClassRouteStandard DosagePrice
LevsinAnticholinergicsInjection0.5, 0.125 MG/MLfrom$8.63
OsciminAnticholinergicsOral0.125, 0.375 MGfrom$8.63
RobinulAnticholinergicsOral2, 1 MGfrom$10.60
Dartisla ODTAnticholinergicsOral1.7 MGfrom$169.75
LibraxAnticholinergic / Benzodiazepine CombinationsOral5-2.5 MGfrom$15.24
AnaspazAnticholinergicsOral0.125 MGfrom$7.69
Symax-SLAnticholinergicsSublingual0.125 MGfrom$8.63
HyosyneAnticholinergicsOral0.125 MG/MLfrom$16.20
Oscimin SRAnticholinergicsOral0.375 MGfrom$14.39
Symax-SRAnticholinergicsOral0.375 MGfrom$14.39


Peptic Ulcer Disease (PUD) is a common ailment that affects the digestive system, particularly the stomach and the first part of the small intestine (duodenum). It is characterized by the formation of open sores or ulcers in the lining of these organs, leading to abdominal pain, discomfort, and various complications if left untreated. PUD is a chronic condition that requires long-term management and may significantly impact a person's quality of life.


The primary cause of Peptic Ulcer Disease is the imbalance between stomach acid and protective factors in the digestive system. Previously, it was believed that stress and consumption of spicy foods directly cause ulcers. However, research has shown that the major culprits are the bacteria Helicobacter pylori (H. pylori) and the use of nonsteroidal anti-inflammatory drugs (NSAIDs). H. pylori are commonly found in the stomach and duodenum, and this bacterial infection weakens the protective lining of the stomach, making it more susceptible to damage from acid. NSAIDs, such as aspirin and ibuprofen, can also irritate the stomach lining and lead to ulcer formation when used in high doses or over prolonged periods.


The symptoms of Peptic Ulcer Disease can vary in severity and may come and go over time. Some individuals with PUD may experience no symptoms at all. Common signs and symptoms include a burning or gnawing pain in the upper abdomen, typically occurring between meals and often relieved by antacids or food. Other symptoms may include nausea, vomiting, bloating, belching, weight loss, and a loss of appetite. In severe cases, complications such as bleeding, perforation (creating a hole), or obstruction of the stomach or intestine may occur and require immediate medical attention.


To diagnose Peptic Ulcer Disease, healthcare professionals typically perform a thorough medical history assessment and physical examination. They may also recommend certain tests to confirm the presence of an ulcer. Common diagnostic procedures include an endoscopy, where a thin tube with a camera is inserted through the mouth to visualize the digestive tract, and a biopsy to test for H. pylori infection. Blood tests, stool tests, and breath tests may also be utilized to detect the presence of H. pylori or other factors contributing to ulcer development.


The treatment of Peptic Ulcer Disease is aimed at relieving symptoms, promoting healing, and preventing complications. In most cases, a combination of therapies is required. Treatment strategies usually involve the use of medications to reduce stomach acid production, kill H. pylori bacteria, and protect the lining of the stomach and duodenum. Commonly prescribed medications include proton pump inhibitors (PPIs), antibiotics, and antacids. Lifestyle modifications, such as avoiding NSAIDs and managing stress, can also be beneficial in managing PUD.


Preventing Peptic Ulcer Disease primarily involves minimizing the risk factors. It is important to take prescribed medications as directed and avoid overusing NSAIDs. If H. pylori infection is detected, prompt treatment with antibiotics is essential to eradicate the bacteria and prevent ulcer recurrence. Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and stress management, can also contribute to preventing PUD. Remember, it is crucial to consult a healthcare professional for an accurate diagnosis and appropriate treatment plan for Peptic Ulcer Disease. With timely intervention and proper management, most individuals with PUD can lead a symptom-free life and avoid complications.