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Cortrophin Gel is a medication used to treat various conditions, but it's important to be aware of certain risks associated with its use. This medication should not be administered intravenously. It is contraindicated in individuals with specific health conditions, including scleroderma, osteoporosis, systemic fungal infections, ocular herpes simplex, recent surgery, a history of or current peptic ulcers, congestive heart failure, hypertension, primary adrenocortical insufficiency, adrenocortical hyperfunction, or known sensitivity to proteins derived from pigs.

Prolonged use of Cortrophin Gel can suppress the body's natural production of cortisol, leading to adrenal insufficiency. To minimize this risk, it's essential to gradually reduce the dosage under medical supervision when discontinuing the medication. Additionally, Cortrophin Gel may increase susceptibility to infections and mask their symptoms, making it harder to detect new infections. Patients should be closely monitored for signs of infection during treatment.

The medication can also cause elevated blood pressure, fluid retention, and low potassium levels. Dietary adjustments, such as reducing salt intake or taking potassium supplements, may be necessary to manage these effects. Furthermore, Cortrophin Gel may suppress the signs and symptoms of chronic diseases without altering their natural course, potentially delaying accurate diagnosis and treatment.

Psychiatric reactions, including mood swings, personality changes, and depression, may occur during treatment. Existing mental health conditions could be exacerbated. Long-term use may lead to eye problems like cataracts and glaucoma, which can damage the optic nerves. Patients should avoid receiving smallpox vaccinations while on Cortrophin Gel, and other immunizations should be approached with caution due to potential neurological complications and reduced antibody response.

Individuals with hypothyroidism or cirrhosis may experience an enhanced effect of the medication. Those with latent tuberculosis should be monitored closely for reactivation of the disease. Cortrophin Gel should be used cautiously in patients with diabetes, abscesses, pyogenic infections, diverticulitis, renal insufficiency, and myasthenia gravis. In infants and children undergoing prolonged therapy, growth and development should be carefully observed. Treatment for acute gouty arthritis should be limited to a few days, with conventional therapy continued during and after Cortrophin Gel use to prevent rebound attacks. Aspirin should be used cautiously in conjunction with Cortrophin Gel in individuals with hypoprothrombinemia. Since fetal abnormalities have been observed in animal studies, Cortrophin Gel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

When using Cortrophin Gel, it's important to be aware of potential interactions with other medications and substances. This medication can interact with various drugs, leading to increased risks or reduced effectiveness.

Serious Interactions:

• Amphotericin B deoxycholate: Combining this antifungal with Cortrophin Gel may lead to low potassium levels (hypokalemia). It's advisable to avoid this combination or consider alternative treatments.

• Certain cancer therapies (e.g., axicabtagene ciloleucel, brexucabtagene autoleucel): Using Cortrophin Gel alongside these treatments can heighten immunosuppressive effects, increasing infection risk. Alternative therapies should be considered.

• Live vaccines (e.g., influenza virus vaccine, cholera vaccine): Cortrophin Gel can diminish the effectiveness of live vaccines. It's recommended to avoid live vaccinations during treatment.

Interactions Requiring Close Monitoring:

• Diuretics (e.g., Hydrochlorothiazide, Furosemide): Combining these with Cortrophin Gel may enhance electrolyte loss, leading to imbalances. Regular monitoring of electrolyte levels is essential.

• Fluoroquinolone antibiotics (e.g., Ciprofloxacin, Levofloxacin): Concurrent use may increase the risk of tendon rupture. Patients should be monitored for signs of tendon damage.

• Insulin and oral diabetes medications: Cortrophin Gel can raise blood sugar levels, potentially reducing the effectiveness of diabetes treatments. Blood glucose should be closely monitored, and medication adjustments may be necessary.

Dietary Considerations:

• High-sodium foods: Cortrophin Gel can cause the body to retain salt and water, leading to increased blood pressure. It's advisable to limit salt intake during treatment.

General Advice:

Always inform your healthcare provider about all medications, supplements, and over-the-counter drugs you're taking before starting Cortrophin Gel. This ensures potential interactions are identified and managed appropriately.