Cosyntropin

Drug Details

Cosyntropin is a synthetic form of adrenocorticotropic hormone (ACTH) used primarily to assess adrenal gland function. Administered via injection, it stimulates the adrenal cortex to release cortisol and other hormones. This response helps diagnose conditions like adrenal insufficiency, including Addison's disease. The test involves measuring cortisol levels before and after cosyntropin administration; a normal response typically shows a significant increase in cortisol. Certain medications, such as glucocorticoids, spironolactone, and estrogen-containing drugs, can affect test accuracy and may need to be discontinued prior to testing. While generally safe, cosyntropin can cause side effects like allergic reactions, changes in heart rate, and blood pressure fluctuations. It's important to inform your healthcare provider about all medications and health conditions before undergoing this test.