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When taking this medication, you might experience mild side effects such as constipation or stomach upset. These are generally manageable, but if they persist or worsen, it is important to consult a healthcare professional. Serious side effects, though less common, require immediate attention. These include symptoms like persistent nausea or vomiting, a loss of appetite, unexpected weight loss, mood changes, or signs of kidney issues, such as altered urine output. Additionally, experiencing bone or muscle pain, headaches, increased thirst and urination, feelings of weakness or fatigue, and a rapid or pounding heartbeat, should prompt a discussion with your healthcare provider.

Allergic reactions to this drug are rare but can be severe. Seek urgent medical help if you notice symptoms such as a rash, itching, swelling particularly of the face, tongue, or throat, severe dizziness, or difficulty breathing. While this list covers several potential side effects, it's not exhaustive. If you experience any other symptoms, it is advisable to reach out to your healthcare provider for guidance.

Certain products can interact with this medication, including Digoxin and phosphate binders. Calcium present in this product can hinder the absorption of specific drugs such as tetracycline antibiotics (e.g., doxycycline, Minocycline), bisphosphonates (e.g., Alendronate), estramustine, Levothyroxine, and quinolone antibiotics (e.g., Ciprofloxacin, Levofloxacin). Additionally, some medications like bile acid sequestrants (e.g., Cholestyramine, Colestipol), Mineral Oil, and Orlistat may reduce the absorption of vitamin D. It's important to space out your doses of these medications from your calcium/vitamin D doses. Consult with your doctor or pharmacist to determine the appropriate timing between doses and to create a suitable dosing schedule.

Be sure to check all your prescription, over-the-counter, and herbal products (such as antacids, laxatives, vitamins) for calcium, phosphate, or vitamin D content, and speak with your pharmacist about their safe use. Avoid using medications containing Calcitriol while taking vitamin D, as they are similar. This product might affect certain lab tests, such as cholesterol tests, and could lead to inaccurate results. Inform lab personnel and your healthcare providers if you are using this product.