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When using nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, it is important to be aware of potential risks and necessary precautions. Here is a summary of key safety information:

• Heart Risks: Ibuprofen may increase the risk of heart attack or stroke, which can occur at any time during treatment, and is more likely with prolonged use. This risk is heightened for older adults and individuals with heart disease or risk factors such as smoking, family history of heart problems, high blood pressure, or diabetes. Avoid using this medication immediately before or after heart bypass surgery (CABG).

• Gastrointestinal Bleeding: There is a rare risk of serious, potentially fatal bleeding in the stomach or intestines. This can happen without warning and at any point during treatment, with older adults being more susceptible.

• Emergency Signs: Discontinue use and seek immediate medical attention if you experience severe stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, unilateral weakness, difficulty speaking, or sudden changes in vision.

• Consultation: Discuss with your doctor or pharmacist to thoroughly understand the benefits and risks of ibuprofen use, especially if you have pre-existing health conditions or concerns.

This information is crucial for making informed decisions about using ibuprofen safely. Always follow the guidance of healthcare professionals regarding its use.

This medication may cause some mild side effects, such as an upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness. These are generally not serious and often improve as your body adjusts. Monitoring is recommended if these persist or worsen. Additionally, this medication might raise your blood pressure, so regular checks are advised.

While serious side effects are less common, they require immediate attention. These include easy bruising or bleeding, hearing changes like ringing in the ears, mental or mood changes, an unexplained stiff neck, and signs of kidney issues such as changes in urine output. Symptoms indicating heart failure, like swelling of the ankles or feet, unusual tiredness, or sudden weight gain, should also be promptly addressed.

Rare but severe liver disease can occur with this medication. Seek urgent medical help if you experience persistent nausea or vomiting, loss of appetite, dark urine, abdominal pain, or yellowing of the skin or eyes. Though a serious allergic reaction is rare, watch for symptoms such as fever, swollen lymph nodes, rash, itching or swelling (especially on the face, tongue, or throat), severe dizziness, or trouble breathing.

This summary does not cover all possible side effects. If you encounter any other unusual effects, consulting a healthcare professional is advised.

This medication can interact with several other drugs. Some of these include Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Valsartan and Losartan, Cidofovir, corticosteroids like Prednisone, Lithium, and diuretics like Furosemide. Additionally, this drug may increase your risk of bleeding if taken with other medications that also cause bleeding, such as anti-platelet drugs like Clopidogrel and blood thinners including Dabigatran, Enoxaparin, and Warfarin.

It's important to carefully read the labels of all your prescription and over-the-counter medications, as many contain pain relievers or fever reducers like Aspirin and NSAIDs such as Celecoxib, Ketorolac, or Naproxen. These are similar to Ibuprofen and can elevate your risk of side effects if used together. If you're taking low-dose aspirin (81-162 milligrams daily) for heart attack or stroke prevention, continue doing so unless advised otherwise by your doctor. Be aware that regular ibuprofen use may reduce aspirin's effectiveness in preventing heart attack or stroke. Discuss with your doctor about possibly using Acetaminophen for pain or fever instead. If you need to take ibuprofen, consult your doctor about using immediate-release aspirin instead of enteric-coated aspirin. When using both, take ibuprofen at least 8 hours before or at least 2 hours after your aspirin dose. Do not adjust your aspirin dosage or alter how you take aspirin or any other medications without your doctor’s guidance.