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Here is important safety information regarding the use of Cyclomydril (cyclopentolate / phenylephrine). It is essential to follow these guidelines to minimize potential risks and ensure the medication is used safely. Should you have any questions or concerns, please contact your healthcare provider.

• Application: Cyclomydril is intended exclusively for ocular use. Avoid injecting or ingesting the medication, as this may lead to severe adverse effects, particularly in infants and children.

• Use in Infants and Children: This medication can lead to mood and behavioral changes in infants and young children. An excessive amount may result in serious symptoms, including seizures, hallucinations, impaired coordination, confusion, and restlessness. Monitor children closely for at least 30 minutes following application. In the event of suspected overdose, contact a healthcare provider or the poison control center at 1-800-222-1222 immediately. Do not feed infants for four hours post-application to prevent potential gastrointestinal issues such as upset stomach and diarrhea.

• Eye Pressure Increase: A temporary increase in eye pressure may occur after using Cyclomydril. Individuals with untreated glaucoma or conditions like Down syndrome, which predispose them to eye issues, should inform their healthcare provider of their complete ocular history before use. Risk factors include a history of untreated narrow-angle glaucoma and medications used to lower eye pressure.

• Contraindications: Cyclomydril should not be used in individuals with untreated narrow-angle glaucoma due to the risk of serious health complications. Consult your healthcare provider if this condition applies to you.

These guidelines are designed to ensure safe and effective use of Cyclomydril. Always follow your healthcare provider's instructions and report any adverse effects immediately.

When using Cyclomydril, it's important to be aware of potential interactions with other substances:

Caffeine: Consuming large amounts of caffeine—found in coffee, tea, colas, chocolate, and some herbal supplements—while using Cyclomydril may intensify side effects such as nausea, nervousness, palpitations, sleep disturbances, rapid heartbeat, or tremors. It's advisable to limit caffeine intake during treatment.

Medications: Cyclomydril may interact with certain drugs, including carbachol, pilocarpine, and ophthalmic cholinesterase inhibitors. Combining these medications can alter their effectiveness or increase the risk of side effects. Always inform your healthcare provider about all medications and supplements you are currently taking to ensure safe use of Cyclomydril.

Health Conditions: Individuals with untreated or uncontrolled narrow-angle glaucoma should not use Cyclomydril, as it can exacerbate this condition. Additionally, those with heart disease, high blood pressure, or thyroid disorders should consult their doctor before using this medication, as it may affect these conditions.

By being mindful of these interactions and discussing your full medical history and current medications with your healthcare provider, you can use Cyclomydril safely and effectively.