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When using nonsteroidal anti-inflammatory drugs like diclofenac, it's important to be aware of potential risks and take necessary precautions. Here's what you should consider:

• There is a rare possibility that diclofenac could increase the risk of a heart attack or stroke. This risk can arise at any time during treatment, especially with long-term use, and may be higher for older adults or individuals with heart disease or risk factors such as smoking, family history of heart disease, high blood pressure, or diabetes.
• Diclofenac should not be used immediately before or after undergoing heart bypass surgery (CABG).
• This medication can sometimes cause serious, potentially fatal bleeding in the stomach or intestines, which may occur without warning. The risk of this side effect is greater in older adults.
• If you experience any of the following severe side effects, stop taking diclofenac and seek immediate medical attention: persistent stomach or abdominal pain, black or bloody stools, vomit that resembles coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, sudden vision changes, or trouble speaking.
• It is essential to discuss with your doctor or pharmacist to fully understand the benefits and risks of using this medication.

Always consult with your healthcare provider for personalized advice and guidance.

When using this medication, some individuals might experience mild skin irritation, such as dryness, redness, or stinging. Additionally, feelings of drowsiness or dizziness could occur. These effects are usually manageable, but if they persist or worsen, it's important to inform your healthcare provider. The medication may also cause an increase in blood pressure, so it's advisable to monitor it regularly and consult your healthcare provider if it becomes elevated.

On a more serious note, there are rare but significant side effects to be aware of. The medication may lead to kidney problems, indicated by changes in urine output, or symptoms of heart failure, such as swollen ankles or feet, unusual fatigue, or sudden weight gain. In very rare cases, it can cause severe liver damage, which requires immediate medical attention. Symptoms to watch for include persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the skin or eyes, and dark urine.

Allergic reactions to this drug are uncommon but can be severe. Seek emergency help if you experience symptoms like fever, swollen lymph nodes, rash, itching, swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing. If you observe any other unusual effects not mentioned here, it's crucial to reach out to your healthcare provider for further advice.

This medication can interact with several other drugs. It may have interactions with Aliskiren, ACE inhibitors like Captopril and Lisinopril, and angiotensin II receptor blockers such as Losartan and Valsartan. Additionally, it can interact with Cidofovir, corticosteroids like Dexamethasone and Prednisone, Lithium, Methotrexate, and diuretics such as Furosemide. Combining this medication with other drugs that increase bleeding risk, like anti-platelet medications such as Clopidogrel and blood thinners including Dabigatran, Enoxaparin, and Warfarin, may heighten the chance of bleeding.

It's important to thoroughly review all your prescription and nonprescription medication labels. Many drugs contain pain relievers or fever reducers, including Aspirin and NSAIDs like Ibuprofen, Ketorolac, or Naproxen, which are similar to Diclofenac and might raise the risk of side effects if used together. However, if your healthcare provider advises you to take low-dose aspirin (81-162 milligrams daily) for heart attack or stroke prevention, continue to do so unless directed otherwise by your doctor. For further guidance, consult your doctor or pharmacist.