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This medication is used to manage irregular heartbeats effectively, but it may occasionally lead to a new, severe irregular heartbeat. Here are essential safety guidelines and warnings you should consider:

• Arrhythmias Risk: Tikosyn (dofetilide) can induce serious and potentially life-threatening arrhythmias. Because of this, it is critical for you to be hospitalized for at least three days when beginning or resuming treatment. During this period, medical professionals will monitor your heart's electrical activity with electrocardiograms (EKGs) and adjust your dosage according to your kidney function. Immediate medical attention is necessary if you experience symptoms such as chest pain, dizziness, fainting, or a rapid heartbeat.

• Drug Interactions: Tikosyn (dofetilide) may interact with various medications, increasing its blood levels and risk of side effects. Avoid taking cimetidine (Tagamet HB), trimethoprim (found in Bactrim or Septra), or ketoconazole while using this medication.

• Electrolyte Imbalance: Combining Tikosyn (dofetilide) with certain diuretics can cause low potassium and magnesium levels, heightening the risk of severe heart rhythm issues. Your healthcare provider will monitor your electrolyte levels throughout the treatment.

• Kidney Function Adjustments: Since the kidneys help eliminate Tikosyn (dofetilide) from the body, those with impaired kidney function may require a dosage adjustment to prevent accumulation and increased side effects. Your healthcare provider will evaluate your kidney function through blood tests to determine a safe and effective dose. Inform your provider of any kidney issues you have.

Contraindications: Avoid using Tikosyn (dofetilide) if you have severe kidney problems, a heart rhythm condition called long QT syndrome, or if you are taking specific interacting medications. Consult your healthcare provider if any of these conditions apply to you before starting this medication.

Adhering to these safety measures ensures the medication is used effectively while minimizing potential risks.

Common side effects:

• Headache
• Dizziness
• Nausea
• Respiratory tract infections
• Shortness of breath
• Diarrhea
• Stomach pain
• Back pain
• Difficulty sleeping
• Flu-like symptoms
• Rash

Serious side effects:

• Chest pain
• Fainting
• Fast or irregular heartbeat
• Severe dizziness
• Very serious allergic reaction
• Itching or swelling of the face, tongue, or throat
• Trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Cimetidine
• Dolutegravir
• Fingolimod
• Amiodarone
• Pimozide
• Procainamide
• Quinidine
• Sotalol

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Clarithromycin
• Erythromycin
• Sparfloxacin
• Hydrochlorothiazide
• Itraconazole
• Ketoconazole
• Lamotrigine
• Megestrol
• Prochlorperazine
• Tafenoquine
• Trilaciclib
• Trimethoprim
• Verapamil