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The information below outlines crucial safety details and warnings for the use of Doxylamine (Unisom SleepTabs). It is important to read through these carefully and discuss any concerns with your healthcare provider.

• Drowsiness Risk: Doxylamine (Unisom SleepTabs) may cause significant drowsiness that can impair focus, cognitive function, and reaction time. This effect is more pronounced if you are over 65 years old, consume alcohol, or take other drowsiness-inducing medications such as opioids, benzodiazepines, or sleep aids. Avoid alcohol and any other substances that may increase drowsiness while taking this medication. Refrain from driving or operating machinery until you are aware of how Doxylamine affects you.

• Exacerbation of Existing Conditions: Consult your healthcare provider before taking Doxylamine (Unisom SleepTabs) if you have conditions like glaucoma, urinary problems (e.g., enlarged prostate, bladder neck obstruction), or breathing disorders (e.g., emphysema or chronic bronchitis). These conditions may worsen, potentially leading to severe side effects. Ensure your healthcare provider is informed about all your current and past medical conditions.

• Accidental Overdose Risk: Doxylamine (Unisom SleepTabs) is an antihistamine found in many over-the-counter medications. Taking multiple antihistamine-containing products can cause adverse effects such as blurry vision, skin redness, and confusion. Always check medication labels and avoid combining products with similar active ingredients.

In the event of an overdose or severe side effects, seek immediate medical attention.

Common side effects:

• Sleepiness
• Difficulty concentrating
• Dizziness

Less common but important to monitor:

• Constipation
• Trouble urinating
• Urinary retention
• Blurry or double vision

Serious side effects:

• Excessive sleepiness or dizziness
• Fast heartbeat
• Flushing
• Extreme sleepiness
• Hallucinations
• Changes in vision
• Irritability in children

When taking doxylamine, it's important to be aware of potential interactions with other substances, as these can affect how the medication works and may increase the risk of side effects.

Central Nervous System (CNS) Depressants: Combining doxylamine with other medications that cause drowsiness can lead to enhanced sedative effects. This includes prescription pain relievers like codeine and hydrocodone, sleep aids, anxiety medications such as Alprazolam and Lorazepam, muscle relaxants like Carisoprodol and Cyclobenzaprine, and other antihistamines such as diphenhydramine. Using these substances together may result in increased drowsiness, dizziness, and impaired coordination.

Alcohol: Consuming alcohol while taking doxylamine can intensify drowsiness and increase the risk of side effects. It's advisable to avoid alcoholic beverages during treatment.

Monoamine Oxidase Inhibitors (MAOIs): Doxylamine should not be used with MAOIs, a class of medications used to treat depression. Combining these can prolong and intensify the anticholinergic effects of doxylamine, leading to increased drowsiness and other side effects.

Other Antihistamines: Using multiple antihistamines simultaneously, including those applied to the skin like diphenhydramine creams or sprays, can increase the risk of side effects. It's important to read medication labels carefully to avoid unintentional duplication.

Herbal Supplements: Certain herbal products, such as Melatonin and valerian, can also cause drowsiness. Taking these with doxylamine may lead to increased sedation.

Always inform your healthcare provider about all medications, supplements, and herbal products you are currently using to ensure safe and effective use of doxylamine.