HomeDrug ClassesBarbiturate / Acetaminophen Combinations

Barbiturate / Acetaminophen Combinations: Uses, Common Brands, and Safety Info

"Barbiturate / Acetaminophen combinations are prescription drugs used for pain relief. Common brands include Fioricet, Esgic, and Bupap. They should be used with caution due to addiction potential, liver toxicity, and potential drug interactions."


Barbiturate / Acetaminophen combinations are a class of drugs that consist of a barbiturate and acetaminophen. Barbiturates are central nervous system depressants, commonly used to treat anxiety, tension, insomnia, and seizures. Acetaminophen, on the other hand, is a pain reliever and fever reducer. When combined, these two drugs can provide a synergistic effect in treating certain conditions. These combinations are mostly used to relieve mild to moderate pain, including headaches, toothaches, muscle aches, menstrual cramps, and pain associated with colds and flu. They may also be prescribed for the treatment of tension headaches or to reduce fever.

Common Brands

There are a few common brands that offer barbiturate / acetaminophen combinations. Some of the well-known brands include: 1. Fioricet: This brand contains the barbiturate butalbital, acetaminophen, and caffeine. It is commonly prescribed for tension headaches. 2. Esgic: Esgic is another brand that combines butalbital with acetaminophen. It is used for the relief of tension headaches. 3. Bupap: Bupap contains the barbiturate butalbital combined with acetaminophen. It is also used to treat tension headaches. It is important to note that the availability of these brands may vary depending on the country and region. Additionally, other generic versions of barbiturate / acetaminophen combinations may be available in the market.


While barbiturate / acetaminophen combinations can be effective for certain conditions, it is essential to use them safely and responsibly. Here are a few safety considerations: 1. Prescription Only: Barbiturate / acetaminophen combinations are prescription drugs and should only be taken under the guidance of a healthcare professional. It is important not to exceed the recommended dosage or duration of use. 2. Addiction Potential: Barbiturates have the potential for dependence and addiction. Long-term use or misuse of these combinations can lead to physical and psychological dependence. It is crucial to follow the prescribed dosage and avoid prolonged use. 3. Liver Toxicity: Acetaminophen, if taken in excessive amounts, can cause liver damage. It is important to adhere to the recommended dosage and avoid consuming other medications containing acetaminophen simultaneously. 4. Drug Interactions: Barbiturate / acetaminophen combinations may interact with other medications, including blood thinners, sedatives, and certain antidepressants. It is crucial to inform your healthcare provider about all the medications you are taking to minimize the risk of potential interactions. 5. Pregnancy and Breastfeeding: These combinations should be used with caution during pregnancy and while breastfeeding. It is important to consult a healthcare professional to assess the potential risks and benefits. In conclusion, barbiturate / acetaminophen combinations are a class of prescription drugs that effectively treat mild to moderate pain, especially tension headaches. Various brands are available in the market, including Fioricet, Esgic, and Bupap. However, these combinations should be used with caution, following the prescribed dosage and under the supervision of a healthcare professional to ensure safety and minimize potential risks.