HomeDrug ClassesBarbiturate / NSAID Combinations

Barbiturate / NSAID Combinations: Uses, Common Brands, and Safety Info

Barbiturate / NSAID combinations are drugs that combine the sedative effects of barbiturates with the pain-relieving and anti-inflammatory properties of NSAIDs. They are used for conditions involving pain and inflammation, such as tension headaches and arthritis. Common brands include Fiorinal and Fioricet. These medications should be used under medical supervision, following recommended dosages and safety guidelines to minimize risks.


Barbiturate / NSAID combinations are a class of drugs that combine the properties of barbiturates and non-steroidal anti-inflammatory drugs (NSAIDs). Barbiturates are central nervous system depressants that act as sedatives and hypnotics, while NSAIDs are medications used primarily for their analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) effects. The combination of these two drug classes can be beneficial for certain conditions that involve both pain and inflammation. This includes conditions such as tension headaches, migraines, and certain types of arthritis, where both pain relief and reduction of inflammation are necessary for effective treatment.

Common Brands

There are several common brands of barbiturate / NSAID combinations available on the market. Some examples include: 1. Fiorinal: This combination medication contains butalbital (a barbiturate), aspirin (an NSAID), and caffeine. It is commonly used for tension headaches. 2. Fioricet: Similar to Fiorinal, Fioricet also contains butalbital, acetaminophen (a non-NSAID pain reliever), and caffeine. It is often prescribed for tension headaches or migraines. 3. Ascomp with Codeine: This combination medication includes butalbital, aspirin, caffeine, and codeine. It is used for the relief of tension headaches and also provides mild to moderate pain relief. It's important to note that the availability and specific brand names of barbiturate / NSAID combinations may vary depending on the country and local regulations.


Barbiturate / NSAID combinations should only be used under the supervision and guidance of a healthcare professional. They are prescription medications and should be taken exactly as prescribed. It is important to follow the recommended dosage and duration of treatment to minimize the risk of potential side effects or drug interactions. Like any medication, barbiturate / NSAID combinations carry certain safety considerations. This drug class can cause drowsiness, dizziness, and impair cognitive function, so it is essential to avoid activities that require mental alertness until the effects of the medication are known. Additionally, long-term use of barbiturate / NSAID combinations can lead to physical dependence and tolerance, which may require a gradual tapering of the medication under medical supervision. Abrupt discontinuation of these medications can result in withdrawal symptoms such as anxiety, insomnia, and tremors. People with certain medical conditions, such as liver or kidney disease, bleeding disorders, asthma, or a history of substance abuse, should exercise caution when using barbiturate / NSAID combinations. They should inform their healthcare provider about their medical history and any other medications they are taking to avoid potential interactions or contraindications. In summary, barbiturate / NSAID combinations are a class of medications that combine the sedative properties of barbiturates with the pain-relieving and anti-inflammatory effects of NSAIDs. They are commonly used for conditions that involve pain and inflammation, such as tension headaches and certain types of arthritis. However, these medications should only be used under medical supervision, and it is important to follow the recommended dosage and safety guidelines to minimize potential risks.

List of Barbiturate / NSAID Combinations