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Barbiturate / Opioid / Acetaminophen Combinations: Uses, Common Brands, and Safety Info

Barbiturate/Opioid/Acetaminophen Combinations are a class of medications used for moderate to severe pain relief. Common brands include Percocet and Fioricet. Caution must be exercised due to risks of abuse, addiction, and overdose. Proper dosing, awareness of dependence risks, and avoiding interactions with other drugs are important safety considerations. Regular monitoring and communication with healthcare providers are crucial for safe and effective use.


Barbiturate/Opioid/Acetaminophen Combinations are a class of medications that consist of three active ingredients: barbiturates, opioids, and acetaminophen. This combination provides analgesic (pain-relieving) effects by targeting different pain pathways within the body. These drugs are typically used for the management of moderate to severe pain.


The main indication for Barbiturate/Opioid/Acetaminophen Combinations is the relief of pain that is not adequately managed by other analgesics alone. These combinations are commonly prescribed for acute pain following surgeries, severe injuries, or medical procedures. They may also be used for chronic pain management in certain cases, although other treatment options may be considered before resorting to these medications.

Common Brands

There are several commonly used brands of Barbiturate/Opioid/Acetaminophen Combinations, each containing specific combinations and dosages of the active ingredients. Some well-known brands include:

  • Percocet: Combining oxycodone (an opioid) with acetaminophen

  • Fioricet: Combining butalbital (a barbiturate), caffeine, and acetaminophen

  • Fiorinal: Combining butalbital (a barbiturate), aspirin, and caffeine

  • Esgic-Plus: Combining butalbital (a barbiturate), acetaminophen, and caffeine


It is important to use Barbiturate/Opioid/Acetaminophen Combinations with caution due to the potential for abuse, addiction, and overdose associated with opioids and barbiturates. These combinations should only be used as prescribed by a healthcare professional and for the shortest duration necessary. As with all medications, there are some safety considerations to keep in mind when using Barbiturate/Opioid/Acetaminophen Combinations:

  • Proper dosing: Follow the prescribed dose and schedule provided by your healthcare provider. Do not exceed the recommended dose, as this can lead to serious health complications.

  • Risks of dependence: Prolonged use of opioids or barbiturates can lead to physical and psychological dependence. It is important to discuss any concerns about addiction or dependence with your healthcare provider.

  • Interaction with other drugs: Barbiturate/Opioid/Acetaminophen Combinations can interact with other medications, such as sedatives, tranquilizers, or alcohol, leading to increased sedation and respiratory depression. Make sure to inform your healthcare provider about all the medications you are taking.

  • Liver toxicity: Acetaminophen, a component of these combinations, can cause liver damage when taken in high doses or in combination with alcohol. Avoid excessive acetaminophen intake and alcohol consumption.

It is crucial to consult with a healthcare professional before starting or discontinuing any medication in this class. Regular monitoring and open communication with your healthcare provider are important to ensure the safe and effective use of Barbiturate/Opioid/Acetaminophen Combinations for pain management.