HomeDrug ClassesCalcium Channel Blocker / ARB Combinations

Calcium Channel Blocker / ARB Combinations: Uses, Common Brands, and Safety Info

"Calcium Channel Blocker/ARB Combinations are medications that combine the effects of calcium channel blockers and angiotensin II receptor blockers. They are commonly used to treat hypertension and other cardiovascular conditions. Common brands include Exforge, Azor, Twynsta, and Tribenzor. While generally safe, these combinations may cause side effects and interact with other medications. Patients should consult their healthcare provider before use."


Calcium Channel Blocker/ARB Combinations are a class of medications that combine the therapeutic effects of both calcium channel blockers (CCBs) and angiotensin II receptor blockers (ARBs). These medications work synergistically to relax the blood vessels, lower blood pressure, and improve blood flow. This combination therapy is often prescribed for patients who have not responded well to treatment with either medication alone.


Calcium Channel Blocker/ARB Combinations are primarily used to treat hypertension (high blood pressure). By blocking the entry of calcium into the smooth muscle cells lining the blood vessels, CCBs help to reduce the constriction of these vessels, leading to improved blood flow and decreased blood pressure. The addition of ARBs further enhances the blood pressure-lowering effects by selectively blocking the effects of angiotensin II, a hormone that normally constricts blood vessels. In addition to hypertension, these combinations may also be prescribed to manage other cardiovascular conditions such as angina (chest pain), certain arrhythmias (abnormal heart rhythms), and heart failure. They can be especially beneficial for individuals who have both high blood pressure and coexisting cardiovascular conditions.

Common Brands

There are several common brands of Calcium Channel Blocker/ARB Combinations available on the market. Examples include: 1. Exforge (amlodipine/valsartan) 2. Azor (amlodipine/olmesartan) 3. Twynsta (telmisartan/amlodipine) 4. Tribenzor (olmesartan/amlodipine/hydrochlorothiazide) It is important to note that these brand names may vary depending on the country and region.


Calcium Channel Blocker/ARB Combinations are generally considered safe when used as directed by a healthcare professional. However, like any medication, they may cause certain side effects. The most common side effects include dizziness, headache, flushing, swelling of the ankles, and low blood pressure. These side effects are usually mild and transient. Patients taking these combinations should be aware of potential drug interactions. Certain medications, such as other blood pressure-lowering drugs or diuretics, may interact with CCBs and ARBs, leading to an increased risk of hypotension (low blood pressure) or adverse effects. It is important to inform your healthcare provider about all the medications you are taking to ensure they are compatible with Calcium Channel Blocker/ARB Combinations. As with any medication, individuals with pre-existing medical conditions, such as liver or kidney disease, should exercise caution and consult with their healthcare provider before starting this drug class. Pregnant or breastfeeding women should also consult their healthcare provider before using these combinations, as their safety during pregnancy or lactation has not been well established. In conclusion, Calcium Channel Blocker/ARB Combinations are a useful class of medications for managing hypertension and certain cardiovascular conditions. They offer a synergistic effect by combining the benefits of calcium channel blockers and angiotensin II receptor blockers. As always, it is essential to follow the guidance of a healthcare professional when taking any medication to ensure its safe and effective use.

List of Calcium Channel Blocker / ARB Combinations