HomeDrug ClassesCD123-directed cytotoxin

CD123-directed cytotoxin: Uses, Common Brands, and Safety Info

CD123-directed cytotoxin is a drug class used to target CD123 protein in certain cancers. It has potential benefits in treating hematologic malignancies like AML and BPDCN. Common brands may vary, and safety precautions should be followed due to potential side effects and interactions with other medications. Ongoing research is necessary to understand the full potential of this treatment option.


CD123-directed cytotoxin is a type of drug class that specifically targets the CD123 protein found on the surface of certain cancer cells. These cytotoxins are designed to bind to the CD123 protein and deliver a toxic payload directly into the cancer cell, leading to its destruction. CD123-directed cytotoxins represent a promising therapeutic approach in the field of oncology, offering potential benefits for patients with specific types of cancer.


CD123-directed cytotoxins are primarily used in the treatment of certain hematologic malignancies. These include acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN), both of which overexpress CD123. By selectively targeting the CD123 protein, these cytotoxins can directly and effectively eliminate cancer cells while sparing healthy cells in the body.

Common Brands

There are several common brands of CD123-directed cytotoxins available in the market today. Brand names may vary based on the specific drug formulation and manufacturer. It is important to consult with a healthcare professional or pharmacist for the most up-to-date and accurate information on the available brands in your region.


When using CD123-directed cytotoxins, it is essential to closely follow the prescribed dosage and administration instructions provided by the healthcare professional. These drugs may be administered intravenously and can have potential side effects, which should be discussed with the treating physician. Common side effects may include nausea, fatigue, infusion-related reactions, and myelosuppression (decreased production of blood cells). Like all medications, CD123-directed cytotoxins can interact with other drugs or substances. Therefore, patients should inform their healthcare provider about any other medications, supplements, or herbal products they are currently taking. Additionally, individuals with known allergies to any components of the drug should exercise caution and communicate this to their medical team to avoid adverse reactions. As with any cancer treatment, CD123-directed cytotoxins are subject to ongoing research and advancements. It is crucial for patients to discuss the potential benefits and risks of this treatment option with their healthcare provider to make an informed decision based on their specific condition and medical history.