HomeDrug ClassesCD20 Antibodies

CD20 Antibodies: Uses, Common Brands, and Safety Info

CD20 antibodies are medications used to treat autoimmune disorders and hematologic malignancies by targeting B cells. Common brands include rituximab, ofatumumab, and obinutuzumab. They can help suppress the immune response and slow down cancerous cell growth. Side effects may occur, and monitoring is essential during treatment. Consult a healthcare professional for personalized advice.

CD20 Antibodies

CD20 antibodies are a class of medications that target the protein CD20 found on B cells, a type of white blood cell involved in the immune response. By binding to CD20, these antibodies help to regulate and modify the immune system's activity, making them valuable in the treatment of various diseases.


CD20 antibodies are primarily used in the treatment of certain autoimmune disorders and hematologic malignancies. These medications have been proven effective in managing conditions such as:

  • Rheumatoid arthritis

  • Lupus

  • Multiple sclerosis

  • Chronic lymphocytic leukemia

  • Non-Hodgkin's lymphoma

In autoimmune disorders, CD20 antibodies help suppress an overactive immune response by reducing the number of B cells and decreasing the production of autoantibodies that attack healthy tissues. In hematologic malignancies, these medications can target cancerous B cells directly, slowing down their growth and preventing further disease progression.

Common Brands

Several brands of CD20 antibodies are available in the market. Some of the commonly prescribed ones include:

  • Rituximab (Rituxan)

  • Ofatumumab (Arzerra)

  • Obinutuzumab (Gazyva)

It's important to note that availability and brand names may vary depending on the region and healthcare provider.


CD20 antibodies are generally considered safe and well-tolerated, but like any medication, they carry some risks. Common side effects may include fatigue, nausea, headache, fever, and mild infusion reactions, such as itching or skin rash. Severe allergic reactions and infections are rare but possible.

Before starting treatment with CD20 antibodies, it is crucial to inform your healthcare provider about any pre-existing conditions, current medications, and allergies you may have. These medications may lower the body's ability to fight infections, so precautions should be taken to prevent exposure to contagious illnesses.

Regular monitoring of blood counts and immune function is often necessary during treatment with CD20 antibodies to ensure safety and efficacy. It is essential to follow the prescribed treatment plan and attend all scheduled medical appointments.

In conclusion, CD20 antibodies are a valuable class of medications used to treat autoimmune disorders and hematologic malignancies by targeting B cells. Commonly prescribed brands include rituximab, ofatumumab, and obinutuzumab. While generally safe, CD20 antibodies may cause side effects, and regular monitoring is necessary during treatment. It is important to consult with a healthcare professional for personalized advice and guidance.