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CD22 Antibodies: Uses, Common Brands, and Safety Info

CD22 antibodies are medications used to treat certain types of cancer by activating the immune system against cancer cells. They are well-tolerated but can have side effects. Common brands include Besponsa, Epratuzumab, Lumiliximab, Polivy, and Avelumab. Patients should be closely monitored for potential adverse reactions.

CD22 Antibodies

CD22 antibodies are a class of medications used in the treatment of certain types of cancer, particularly B-cell malignancies. These drugs target CD22, a protein that is found on the surface of B-cells, a type of white blood cell involved in the immune response. By binding to CD22, these antibodies help to activate the immune system to attack and destroy cancer cells.


CD22 antibodies have shown efficacy in the treatment of various B-cell malignancies, including non-Hodgkin lymphoma, chronic lymphocytic leukemia, and hairy cell leukemia. They are typically used in combination with other chemotherapy agents or targeted therapies as part of a comprehensive treatment regimen.

Common Brands

Several CD22 antibodies have been approved for use in clinical practice. Some of the common brands include: - Inotuzumab ozogamicin (Besponsa) - Epratuzumab - Lumiliximab - Pinatuzumab vedotin (Polivy) - Avelumab (Bavencio) - approved for Merkel cell carcinoma, a rare skin cancer with neuroendocrine features. These brands may be prescribed by healthcare professionals depending on the specific condition being treated and individual patient factors.


CD22 antibodies are generally well-tolerated, but like any medication, they can have potential side effects. Common side effects may include infusion reactions, fatigue, nausea, diarrhea, fever, and decreased appetite. Serious adverse reactions can occur, such as liver toxicity, neutropenia (low white blood cell count), and thrombocytopenia (low platelet count). It is important for patients receiving CD22 antibodies to be closely monitored by their healthcare team for any signs of toxicity or adverse reactions. Patients should inform their healthcare provider about any pre-existing medical conditions, ongoing medications, or allergies before starting CD22 antibody therapy. It is also important to adhere to the recommended dosing schedules and follow-up appointments to ensure the best possible treatment outcomes. In conclusion, CD22 antibodies are a valuable class of medications used in the treatment of B-cell malignancies. They work by targeting CD22 proteins on cancer cells, helping to activate the immune system's response against cancer. With proper monitoring and adherence to treatment guidelines, CD22 antibodies can improve outcomes for patients with these types of cancers.