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Decarboxylase Inhibitors: Uses, Common Brands, and Safety Info

Decarboxylase inhibitors are medications used to treat Parkinson's disease and digestive disorders. They work by blocking enzymes that convert amino acids into neurotransmitters. Common brands include Sinemet and Madopar. Side effects may include nausea and low blood pressure. It is important to consult with healthcare professionals and disclose all medications being taken.

Decarboxylase Inhibitors

Decarboxylase inhibitors are a type of medication used to treat certain conditions and diseases. These drugs work by blocking the action of decarboxylase enzymes in the body, which are responsible for converting specific amino acids into neurotransmitters like dopamine. By inhibiting this process, decarboxylase inhibitors help regulate the levels of neurotransmitters in the brain, leading to improved symptom management and relief.


Decarboxylase inhibitors are primarily used in combination with other medications to treat certain conditions, such as Parkinson's disease and certain types of digestive disorders. In Parkinson's disease, decarboxylase inhibitors are used alongside levodopa therapy to enhance the effectiveness of the medication. Levodopa is converted into dopamine in the brain, and decarboxylase inhibitors prevent the breakdown of levodopa in the bloodstream before it reaches the brain. This results in increased dopamine levels and improved motor symptoms associated with Parkinson's disease. In digestive disorders like gastric ulcers and irritable bowel syndrome, decarboxylase inhibitors are used to inhibit the production of excess acid in the stomach. By preventing the breakdown of specific amino acids, these medications reduce the amount of acid produced, providing relief from symptoms such as heartburn, abdominal pain, and bloating.

Common Brands

There are several common brands of decarboxylase inhibitors available on the market. These include:

  • Carbidopa-Levodopa (Sinemet)

  • Benserazide-Levodopa (Madopar)

  • Methyl dopa (Aldomet)

  • Benserazide (Madopar-HBS)

It is essential to consult with a healthcare professional to determine the most appropriate medication and brand based on individual needs and medical history.


Decarboxylase inhibitors are generally safe when used as prescribed, but it is crucial to consider potential side effects and drug interactions. Common side effects may include nausea, dizziness, low blood pressure, and gastrointestinal disturbances. These effects are often transient and resolve with continued use. However, if any severe or persistent side effects occur, it is important to seek medical attention. It is important to inform healthcare professionals of all medications, supplements, and herbal products being taken, as decarboxylase inhibitors can interact with certain medications. MAO inhibitors, antihypertensives, and medications that affect dopamine levels may interact with decarboxylase inhibitors. Additionally, individuals with specific medical conditions, such as liver or kidney disease, should exercise caution and may require dose adjustments. In conclusion, decarboxylase inhibitors are a beneficial class of medications used to treat conditions such as Parkinson's disease and certain digestive disorders. By inhibiting the action of decarboxylase enzymes, these medications help regulate neurotransmitter levels in the brain and reduce symptoms associated with these conditions. Close monitoring and communication with healthcare professionals are essential to ensure the safe and effective use of decarboxylase inhibitors.

List of Decarboxylase Inhibitors