Endothelin Receptor Antagonist / Angiotensin II Receptor Antagonist Combinations: Uses, Common Brands, and Safety Info

Endothelin Receptor Antagonist / Angiotensin II Receptor Antagonist Combinations

Endothelin Receptor Antagonist / Angiotensin II Receptor Antagonist Combinations are a class of medications that combine the actions of two different drugs: endothelin receptor antagonists (ERAs) and angiotensin II receptor antagonists (ARBs). These combinations are used to treat certain cardiovascular conditions, such as pulmonary arterial hypertension (PAH) and diabetic nephropathy.

Uses

Endothelin receptor antagonists work by blocking the effects of endothelin, a hormone that narrows blood vessels and contributes to high blood pressure. Angiotensin II receptor antagonists block the action of a hormone called angiotensin II, which also plays a role in regulating blood pressure. By targeting both pathways, these combination drugs can effectively lower blood pressure and improve cardiovascular function.

These combinations are primarily used in the management of pulmonary arterial hypertension, a serious condition characterized by high blood pressure in the arteries that supply the lungs. By dilating these blood vessels and reducing the workload on the heart, ERAs/ARBs combinations can improve exercise tolerance and reduce symptoms such as shortness of breath and fatigue.

In addition to PAH, ERAs/ARBs combinations may also be prescribed for the treatment of diabetic nephropathy, a complication of diabetes that causes kidney damage. These medications can help slow down the progression of kidney disease by reducing the amount of protein leakage in the urine and improving blood flow to the kidneys.

Common Brands

There are several common brands of Endothelin Receptor Antagonist / Angiotensin II Receptor Antagonist Combinations available on the market. These include:

• Bosentan/valsartan (brand name: Jentadueto)

• Macitentan/valsartan (brand name: Rethymi)

• Ambrisentan/losartan (brand name: Ambelos)

Safety Information

Like any medication, ERAs/ARBs combinations may have potential side effects. It is important to speak with a healthcare provider before starting these medications to understand the risks and benefits.

Common side effects of these combinations may include dizziness, low blood pressure, headache, flushing, and nasal congestion. In some cases, more serious side effects such as liver damage, fluid retention, and blood problems may occur. Regular monitoring of liver function, blood pressure, and blood counts is often necessary while taking these medications.

It is important to note that these combinations are not suitable for everyone. They may interact with other medications, including those for high blood pressure, heart disease, and certain antibiotics. Pregnant women, women planning to become pregnant, and breastfeeding women should avoid these medications due to potential risks to the fetus or infant.

Always follow the prescribed dosage and do not stop or change the medication without consulting a healthcare professional. If any concerning or unusual symptoms occur while taking these combinations, it is essential to seek medical attention promptly.