HomeDrug ClassesExpectorant / Opioid Combinations

Expectorant / Opioid Combinations: Uses, Common Brands, and Safety Info

Expectorant/opioid combinations are medications used to treat coughs and respiratory conditions. They help relieve cough symptoms by promoting mucus expulsion and suppressing the cough reflex. Common brands include Codeine/Guaifenesin and Hydrocodone/Guaifenesin. However, these medications require caution due to the opioid component, as they can cause drowsiness and have the potential for misuse and dependence. It is important to follow healthcare professionals' instructions and report any concerning side effects.


Expectorant/opioid combinations are a class of medications that combine an expectorant drug with an opioid. These drugs are commonly used to relieve symptoms associated with coughs and respiratory conditions. By promoting the expulsion of mucus from the respiratory tract and suppressing the cough reflex, these medications can provide relief for individuals suffering from persistent coughing and excessive mucus production.


The primary use of expectorant/opioid combinations is the management of cough associated with respiratory conditions such as bronchitis, upper respiratory tract infections, and the common cold. These medications are often prescribed when other treatments have failed to adequately control cough symptoms. Expectorant/opioid combinations may be particularly beneficial for individuals experiencing severe or dry coughs that are unresponsive to other medications. In addition to their cough-suppressing properties, expectorant/opioid combinations may also possess mild analgesic effects. This can help alleviate discomfort associated with persistent coughing, as well as provide relief from pain caused by a sore throat and other respiratory symptoms.

Common Brands

Some common brands of expectorant/opioid combinations include: 1. Codeine/Guaifenesin (e.g., Phenergan with Codeine, Cheratussin AC) 2. Hydrocodone/Guaifenesin (e.g., Tussicaps, Hycotuss) 3. Hydrocodone/Chlorpheniramine/Guaifenesin (e.g., Tussionex) It is important to note that availability and specific brand names may vary depending on the country and region.


When using expectorant/opioid combinations, it is essential to prioritize safety to minimize potential risks and side effects. Due to the opioid component of these medications, they have the potential for misuse and dependence. As opioids can cause drowsiness and impair cognitive function, individuals taking expectorant/opioid combinations should exercise caution when driving or operating heavy machinery. These medications are prescription-only, and it is important to follow a healthcare professional's instructions regarding dosage and duration of use. Exceeding recommended doses or using them for an extended period may increase the risk of side effects or opioid addiction. Common side effects of expectorant/opioid combinations may include dizziness, drowsiness, nausea, constipation, and dry mouth. If any concerning side effects occur or worsen, it is important to seek medical advice promptly. It is crucial to inform healthcare providers about any pre-existing medical conditions, such as respiratory disorders, liver or kidney disease, or a history of substance abuse, as these may influence the suitability and safety of expectorant/opioid combinations. Overall, expectorant/opioid combinations can be effective in managing cough symptoms associated with respiratory conditions. However, their use should be closely monitored and reserved for cases where other therapies have been ineffective.

List of Expectorant / Opioid Combinations