HomeDrug ClassesGlitazone / Biguanide Combinations

Glitazone / Biguanide Combinations: Uses, Common Brands, and Safety Info

Glitazone / Biguanide combinations are a drug class used to treat type 2 diabetes. They improve blood sugar control by combining two different medications, glitazones and biguanides. Common brands include Avandamet and Actoplus Met. It is important to consider safety and potential side effects before use.

Glitazone / Biguanide Combinations

Glitazone / Biguanide combinations are a class of drugs that are commonly used in the treatment of type 2 diabetes. These combinations consist of two different types of antidiabetic medications, namely glitazones (also known as thiazolidinediones) and biguanides. By combining these two medications, they work synergistically to help control blood sugar levels in individuals with type 2 diabetes.


This drug class is primarily used to improve glycemic control in patients with type 2 diabetes who have not achieved adequate blood sugar control with either glitazones or biguanides alone. The combination of these medications helps to control blood sugar levels by targeting different mechanisms of action within the body.

Glitazones, such as pioglitazone and rosiglitazone, work by increasing the body's sensitivity to insulin, which helps to lower blood sugar levels. Biguanides, such as metformin, work by decreasing the amount of glucose produced by the liver and improving insulin sensitivity in the muscles. By combining these two medications, the overall effect on blood sugar control is enhanced.

Common Brands

There are several common brand names for glitazone / biguanide combinations. One well-known brand is Avandamet, which combines rosiglitazone and metformin. Another commonly prescribed combination is Actoplus Met, which combines pioglitazone and metformin. These medications are available in different strengths to accommodate individual patient needs.


As with any medication, there are safety considerations to keep in mind when using glitazone / biguanide combinations. It is important to consult with a healthcare professional before starting any new medication to ensure it is appropriate for your specific medical condition.

These combinations may not be suitable for everyone, particularly those with certain medical conditions such as liver disease, kidney disease, or heart failure. They may also interact with other medications, so it is important to inform your healthcare provider about all the medications you are taking.

Common side effects of glitazone / biguanide combinations may include gastrointestinal symptoms such as nausea, diarrhea, and bloating. However, these side effects are usually mild and transient. Rare but serious side effects may include lactic acidosis, which is a buildup of lactic acid in the bloodstream. Symptoms of lactic acidosis can include weakness, difficulty breathing, and stomach pain.

In conclusion, glitazone / biguanide combinations are a useful class of medications for individuals with type 2 diabetes who have not achieved adequate blood sugar control with monotherapy. These combinations help to improve glycemic control by targeting different mechanisms of action. However, it is important to discuss the safety and appropriateness of these medications with a healthcare professional.

List of Glitazone / Biguanide Combinations