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HIV Entry Inhibitors: Uses, Common Brands, and Safety Info

HIV entry inhibitors are antiretroviral drugs used to treat HIV infections by preventing the virus from entering host cells. They are used in combination with other medications and help reduce viral load and improve immune function. Common brands include Maraviroc (Selzentry) and Enfuvirtide (Fuzeon). These drugs have potential side effects, and close monitoring is necessary. Despite the risks, HIV entry inhibitors are crucial in managing HIV infections.

HIV Entry Inhibitors

HIV entry inhibitors are a class of antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV) infections. These medications work by targeting the process of viral entry into host cells, blocking the binding and fusion of the virus to the cell's receptors. By inhibiting this crucial step, HIV entry inhibitors prevent the virus from replicating and spreading within the body.


HIV entry inhibitors are primarily used in combination with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART). They are effective in reducing viral load, slowing disease progression, and improving immune function in individuals infected with HIV.

These medications are particularly beneficial for individuals who have developed resistance to other classes of antiretroviral drugs or for those who experience intolerable side effects from other HIV medications. HIV entry inhibitors can also be used in special cases, such as preventing mother-to-child transmission of HIV during pregnancy and childbirth.

Common Brands

There are several FDA-approved HIV entry inhibitors available in the market, each with its own unique mechanism of action:

  • Maraviroc (brand name Selzentry) - Works by blocking the CCR5 co-receptor on the surface of immune cells, which prevents HIV entry into these cells.

  • Enfuvirtide (brand name Fuzeon) - Acts as a fusion inhibitor, interfering with the fusion of the viral and cellular membranes, thus preventing viral entry into immune cells.

It is essential to note that the availability of specific drugs may vary depending on the region and healthcare system.


As with any medication, HIV entry inhibitors come with potential side effects and should only be used under the supervision of a healthcare professional. It is crucial for individuals taking these drugs to adhere to the prescribed dosage and follow-up with regular monitoring to assess efficacy and safety.

Common side effects of HIV entry inhibitors may include gastrointestinal disturbances, headache, fatigue, and allergic reactions. Severe side effects are rare, but individuals should seek immediate medical attention if they experience symptoms such as difficulty breathing, severe skin reactions, or signs of liver toxicity.

Drug interactions can occur with HIV entry inhibitors, so it is crucial to inform healthcare providers about all other prescription or over-the-counter medications, supplements, or herbal products being taken. Close monitoring is also necessary for individuals with pre-existing liver or kidney conditions, as HIV entry inhibitors may affect these organs.

Overall, HIV entry inhibitors, when used appropriately, play a vital role in managing HIV infections and improving the quality of life for individuals living with the disease.

List of HIV Entry Inhibitors