HomeDrug ClassesHuman Alpha-1 Proteinase Inhibitors

Human Alpha-1 Proteinase Inhibitors: Uses, Common Brands, and Safety Info

"Human Alpha-1 Proteinase Inhibitors: Uses, Brands & Safety" Exploring the use of human alpha-1 proteinase inhibitors for alpha-1 antitrypsin deficiency, common brands like Prolastin-C and Aralast NP, and safety considerations.

Human Alpha-1 Proteinase Inhibitors

Human alpha-1 proteinase inhibitors are a class of drugs used primarily for the treatment of alpha-1 antitrypsin deficiency (AATD), a genetic condition characterized by low levels of the alpha-1 antitrypsin protein in the blood. AATD can lead to the development of lung and liver diseases, including emphysema and cirrhosis. Human alpha-1 proteinase inhibitors work by replenishing the deficient protein in patients with AATD, helping to prevent further damage to the lungs and liver.


The primary use of human alpha-1 proteinase inhibitors is for the treatment of emphysema in patients with AATD. Emphysema is a chronic lung disease characterized by the destruction of lung tissue and narrowing of the airways. By increasing the levels of alpha-1 antitrypsin, these drugs can help protect the lungs from further damage and improve respiratory function in individuals with AATD. In addition to emphysema, human alpha-1 proteinase inhibitors may also be used in the treatment of other respiratory conditions, such as chronic obstructive pulmonary disease (COPD) and bronchiectasis. These drugs are administered intravenously, usually once a week or once every two weeks, under the supervision of a healthcare professional.

Common Brands

There are several brands of human alpha-1 proteinase inhibitors available on the market. One commonly prescribed brand is "Prolastin-C" (alpha-1 proteinase inhibitor [human]). Another brand is "Aralast NP" (alpha-1 proteinase inhibitor [human]). These brands contain purified human alpha-1 proteinase inhibitor derived from human plasma. It is important to note that different brands may have varying dosing instructions and storage requirements, so it is essential to follow the specific directions provided by the prescribing healthcare professional.


Human alpha-1 proteinase inhibitors are generally well-tolerated, with few serious side effects. Common side effects may include headache, fatigue, dizziness, and injection site reactions. However, individuals with known allergies to alpha-1 proteinase inhibitors or any components of the drug should not use these medications. As with any medication, it is important to discuss with your healthcare provider any existing medical conditions or medications you are currently taking before starting treatment with human alpha-1 proteinase inhibitors. They can provide personalized advice and monitor your progress to ensure the most effective and safe treatment. In conclusion, human alpha-1 proteinase inhibitors are a valuable class of drugs used for the treatment of alpha-1 antitrypsin deficiency. These medications help replenish the deficient protein, protecting the lungs from further damage in individuals with AATD. Common brands include Prolastin-C and Aralast NP. While generally safe, it is important to consult with a healthcare professional before starting treatment with these drugs to ensure safety and effectiveness.