HomeDrug ClassesIDH2 Inhibitors

IDH2 Inhibitors: Uses, Common Brands, and Safety Info

IDH2 inhibitors are a class of drugs used in the treatment of certain types of cancer, such as acute myeloid leukemia. They target the mutated IDH2 enzyme and have shown promising results in clinical trials. Common brands include enasidenib (Idhifa) and ivosidenib (Tibsovo). Safety considerations include potential side effects and the need for liver function monitoring. Consultation with a healthcare professional is advised.


IDH2 inhibitors are a class of drugs used in the treatment of certain types of cancer. These inhibitors specifically target the mutated isocitrate dehydrogenase 2 (IDH2) enzyme, which plays a role in the development and progression of cancer. By inhibiting this enzyme, IDH2 inhibitors help to restore normal cellular function and promote tumor regression. This drug class has shown promising results in clinical trials and is being increasingly used as a targeted therapy in cancer treatment.


IDH2 inhibitors are primarily used in the treatment of acute myeloid leukemia (AML), a type of blood cancer that affects the bone marrow and blood cells. These inhibitors are specifically indicated for patients who have a specific mutation in the IDH2 gene, known as IDH2 R140Q or IDH2 R172K. A genetic test is typically conducted to identify patients who may benefit from this targeted therapy. IDH2 inhibitors are often used in combination with other chemotherapy agents or as a monotherapy, depending on the specific needs of the patient.

Common Brands

Two of the most commonly prescribed IDH2 inhibitors are enasidenib and ivosidenib. Enasidenib is marketed under the brand name Idhifa, while ivosidenib is marketed as Tibsovo. These medications are available in oral tablet form, allowing for convenient administration.


As with any medication, there are certain safety considerations to keep in mind when using IDH2 inhibitors. It is important to note that these drugs are associated with some potential side effects, including nausea, vomiting, diarrhea, fatigue, fever, and decreased appetite. Patients undergoing treatment with IDH2 inhibitors should be closely monitored for these side effects and appropriate supportive care should be provided. Additionally, IDH2 inhibitors may interact with other medications, so it is crucial to inform healthcare professionals about all the medications, supplements or herbal products being used. These inhibitors can also affect the liver, so regular monitoring of liver function is necessary during treatment. In conclusion, IDH2 inhibitors are a targeted therapy option used in the treatment of certain types of cancer, particularly acute myeloid leukemia with specific IDH2 mutations. Common brands of IDH2 inhibitors include enasidenib (Idhifa) and ivosidenib (Tibsovo). The safety profile of these drugs involves potential side effects and the need for monitoring during treatment. As with any medication, it's important to consult with a healthcare professional for personalized advice regarding the use of IDH2 inhibitors.

List of IDH2 Inhibitors