HomeDrug ClassesKinase Inhibitor / Prostaglandin Combinations

Kinase Inhibitor / Prostaglandin Combinations: Uses, Common Brands, and Safety Info

Kinase inhibitor/prostaglandin combinations, like Rocklatan, are drugs used to treat glaucoma and ocular hypertension. They lower intraocular pressure by inhibiting kinases and regulating prostaglandin activity. Rocklatan is a common brand in this class. Side effects include eye redness and discomfort. Medical history should be considered before use.


Kinase inhibitor/prostaglandin combinations are a class of drugs that are used to treat various eye conditions, specifically glaucoma. These medications combine the benefits of both a kinase inhibitor and a prostaglandin, offering dual mechanisms of action to effectively lower intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. One of the common brands in this drug class is Rocklatan.


These combinations are primarily used for the treatment of open-angle glaucoma or ocular hypertension, conditions characterized by increased pressure within the eye. By inhibiting specific kinases and regulating prostaglandin activity, these drugs help to decrease the production of fluid in the eye, while also enhancing its outflow. This dual action leads to reduced intraocular pressure, preventing potential damage to the optic nerve and preserving vision.

Common Brands

A well-known brand within the kinase inhibitor/prostaglandin combination drug class is Rocklatan. Rocklatan is a prescription eye drop that contains a kinase inhibitor called netarsudil and a prostaglandin analog known as latanoprost. This combination offers the synergistic effects of both medications, providing improved IOP control compared to using either drug alone. Patients using Rocklatan should follow their healthcare provider's instructions regarding the dosage and administration of this medication.


Like any medication, kinase inhibitor/prostaglandin combinations have potential side effects and safety considerations. Common side effects may include eye redness, stinging or burning sensation, eye discomfort, and changes in eyelash growth. These side effects are usually mild and transient. It is important for patients to report any unusual or severe side effects to their healthcare provider. Individuals with certain medical conditions or allergies may not be suitable candidates for kinase inhibitor/prostaglandin combinations. It is crucial to inform your healthcare provider about your medical history, existing eye conditions, and any medications you are currently taking to ensure the safe and effective use of these drugs. Pregnant or breastfeeding individuals should also consult their healthcare provider before using these medications. In conclusion, kinase inhibitor/prostaglandin combinations, such as Rocklatan, are effective medications used in the management of open-angle glaucoma and ocular hypertension. By targeting multiple pathways involved in regulating intraocular pressure, these drugs provide enhanced IOP control, potentially preserving vision and preventing further complications associated with increased eye pressure. It is always essential to consult with a healthcare provider for personalized advice and guidance regarding the use of any medication.

List of Kinase Inhibitor / Prostaglandin Combinations