HomeDrug ClassesMTP Inhibitors

MTP Inhibitors: Uses, Common Brands, and Safety Info

MTP inhibitors are a drug class used to treat lipid disorders like HoFH and FH. They reduce LDL cholesterol levels and are typically prescribed alongside a low-fat diet and other therapies. Common brands include lomitapide and mipomersen, but these medications require close monitoring due to potential side effects and liver toxicity. Patients should inform their healthcare provider of all medications and follow prescribed dosages and dietary restrictions. Consulting a healthcare professional is crucial before starting or changing any medication regimen.

Drug Class: MTP Inhibitors


MTP (microsomal triglyceride transfer protein) inhibitors are medications used to treat certain lipid disorders, particularly homozygous familial hypercholesterolemia (HoFH) and familial hypercholesterolemia (FH). These rare genetic conditions lead to extremely high LDL cholesterol levels that cannot be adequately controlled with statins alone. MTP inhibitors work by inhibiting the activity of MTP, an essential protein involved in the synthesis and secretion of LDL cholesterol particles in the liver and intestines.


MTP inhibitors primarily help reduce LDL cholesterol levels in patients with HoFH and FH. These drugs are typically prescribed as an adjunct to a low-fat diet and other lipid-lowering therapies, such as statins. By inhibiting MTP, these medications decrease the production of LDL cholesterol, helping to improve lipid profiles and reduce the risk of cardiovascular events associated with high cholesterol levels.

Common Brands

Some common brands of MTP inhibitors include lomitapide and mipomersen. Lomitapide is available under the brand name Juxtapid, while mipomersen is marketed as Kynamro. Both medications are available in oral or subcutaneous forms, respectively. It is important to note that MTP inhibitors are available only by prescription, and their use should be closely monitored by a healthcare provider.


MTP inhibitors are potent medications that should be used with caution due to their potential for adverse effects. Common side effects include gastrointestinal issues such as diarrhea, nausea, and abdominal pain. Additionally, these drugs can cause liver toxicity, which may necessitate regular liver function monitoring during treatment. Due to the risk of hepatotoxicity, MTP inhibitors are contraindicated in patients with active liver disease or elevated transaminase levels. If liver abnormalities occur during treatment, discontinuation of the medication may be necessary. Given the potential for drug interactions, it is crucial to inform your healthcare provider about all other medications, supplements, or herbal products you are currently taking. MTP inhibitors, especially lomitapide, have been associated with teratogenic effects, so they are contraindicated during pregnancy and in women of childbearing potential who are not using effective contraception. It is important to follow the prescribed dosage and any dietary restrictions provided by your healthcare provider when taking MTP inhibitors. Regular monitoring of lipid levels and liver function is crucial during treatment. If you experience any concerning side effects or new symptoms, promptly inform your healthcare provider for appropriate guidance. Consultation with a healthcare professional is essential before starting or modifying any medication regimen, including MTP inhibitors.

List of MTP Inhibitors