HomeDrug ClassesNeurosteroid

Neurosteroid: Uses, Common Brands, and Safety Info

Neurosteroids are naturally occurring compounds that affect the central nervous system. They have therapeutic potential in epilepsy, anxiety, and depression. Common brands include Zulresso and ganaxolone. Neurosteroids are generally safe but should be used under medical guidance to minimize risks and drug interactions.


Neurosteroids, also known as neuroactive steroids, are a class of naturally occurring compounds that have potent effects on the central nervous system. These compounds are synthesized in the brain and play a crucial role in modulating neural activity, neurotransmission, and various physiological processes. Neurosteroids are structurally similar to steroid hormones, such as cortisol and testosterone, but they primarily act within the brain rather than throughout the body.


Neurosteroids have been found to have a range of potential therapeutic uses. One prominent use is in the treatment of epilepsy, particularly in cases of refractory seizures that don't respond well to traditional antiepileptic drugs. Certain neurosteroids, such as allopregnanolone, have demonstrated anticonvulsant properties and can help reduce seizure activity. Research is also exploring the use of neurosteroids in the management of anxiety and depression, as they have been shown to modulate GABAergic neurotransmission, which is involved in mood regulation.

Common Brands

While neurosteroids are naturally produced in the body, synthetic analogues have been developed for therapeutic purposes. One such neurosteroid is brexanolone, which is marketed under the brand name Zulresso. It is approved by the FDA for the treatment of postpartum depression in adult women. Another neurosteroid, ganaxolone, is being investigated for its potential use in the treatment of epilepsy.


Neurosteroids generally exhibit a favorable safety profile. Since they naturally occur in the body, they are typically well-tolerated when administered in therapeutic doses. However, as with any medication, there are potential side effects and precautions to consider. Common side effects may include drowsiness, dizziness, and changes in mood or behavior. It is important to discuss any existing medical conditions or medications with a healthcare professional before starting neurosteroid therapy, as they may interact with other drugs. In conclusion, neurosteroids are a class of compounds that have significant effects on the central nervous system. They hold promise for the treatment of epilepsy, anxiety, and depression, among other conditions. Common brands like Zulresso and ganaxolone have demonstrated therapeutic potential in specific indications. While generally safe, it is crucial to consult with a healthcare provider to ensure the appropriate use and minimize any potential risks or drug interactions.

List of Neurosteroid