HomeDrug ClassesNK1 / Serotonin Antagonist Combinations

NK1 / Serotonin Antagonist Combinations: Uses, Common Brands, and Safety Info

NK1/Serotonin Antagonist Combinations are used to prevent and manage chemotherapy-induced nausea and vomiting (CINV). They work by blocking substance P and serotonin. Common brands include Emend, Akynzeo, and Varubi/Ivemend. Side effects may include fatigue, constipation, and changes in taste. It's essential to inform your healthcare provider about all medications you take and seek immediate medical attention for severe reactions.


NK1/Serotonin Antagonist Combinations belong to a class of drugs that are utilized for the prevention and treatment of certain conditions, particularly those related to chemotherapy-induced nausea and vomiting (CINV). This drug class combines NK1 receptor antagonists, which block the effects of substance P, with serotonin antagonists, which block the action of serotonin. By targeting these two different pathways, NK1/Serotonin Antagonist Combinations provide a more comprehensive approach to managing nausea and vomiting.


NK1/Serotonin Antagonist Combinations are primarily used in combination with other medications to prevent or reduce the severity of acute and delayed nausea and vomiting triggered by chemotherapy. Chemotherapy-induced nausea and vomiting can significantly impact the quality of life for cancer patients, often leading to malnutrition, dehydration, and a decrease in treatment compliance. By incorporating NK1/Serotonin Antagonist Combinations into antiemetic regimens, healthcare providers can offer patients a more effective defense against these distressing side effects. Additionally, some of these combinations have also shown promise in managing postoperative nausea and vomiting.

Common Brands

Several NK1/Serotonin Antagonist Combinations are available on the market, each containing different active ingredients and varying in strength. Some commonly prescribed brands include: - Aprepitant/Fosaprepitant (Emend) - Netupitant/Palonosetron (Akynzeo) - Rolapitant/Granisetron (Varubi/Ivemend) It's important to note that the availability of specific brands may vary depending on the country and healthcare system.


NK1/Serotonin Antagonist Combinations are generally safe and well-tolerated. However, as with any medication, there are potential side effects and precautions to consider. Common side effects of these combinations may include fatigue, constipation, headache, indigestion, and changes in taste perception. Additionally, certain medications within this class can interact with other drugs, particularly those metabolized through specific liver enzymes. It's important to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, to avoid potential drug interactions. Your healthcare provider will also consider your medical history and current health status to determine the most appropriate NK1/Serotonin Antagonist Combination and dosage for you. If you experience severe or persistent side effects or allergic reactions while taking NK1/Serotonin Antagonist Combinations, it is essential to seek immediate medical attention. Your healthcare provider can evaluate your specific situation and make any necessary adjustments to ensure your safety and well-being. In conclusion, NK1/Serotonin Antagonist Combinations are an important class of medications used for the prevention and management of chemotherapy-induced nausea and vomiting. By combining NK1 receptor antagonists and serotonin antagonists, these drugs offer a comprehensive approach to alleviate the distressing side effects associated with chemotherapy. However, it is crucial to follow your healthcare provider's instructions and report any concerning side effects to ensure safe and effective treatment.

List of NK1 / Serotonin Antagonist Combinations