HomeDrug ClassesNSAID / Histamine-2 Antagonist Combinations

NSAID / Histamine-2 Antagonist Combinations: Uses, Common Brands, and Safety Info

"NSAID / Histamine-2 Antagonist Combinations combine pain relief, anti-inflammatory action, and reduction of stomach acid. They are used for conditions like arthritis and menstrual cramps. Common brands include Arthotec and Preotact. Safety precautions include using the lowest effective dose and not exceeding the recommended duration of treatment."

Drug Class: NSAID / Histamine-2 Antagonist Combinations

NSAID / Histamine-2 Antagonist Combinations are a class of medications that combine a nonsteroidal anti-inflammatory drug (NSAID) with a histamine-2 antagonist. This combination provides the benefits of pain relief and anti-inflammatory action, along with reducing stomach acid production. By combining these two types of drugs, this class of medications aims to minimize the gastrointestinal side effects commonly associated with NSAIDs.


NSAID / Histamine-2 Antagonist Combinations are primarily used to treat conditions that involve pain, inflammation, and increased gastric acid production. The NSAID component of the medication helps relieve pain and reduce inflammation, while the histamine-2 antagonist component helps reduce stomach acid production and prevent complications associated with excessive acid, such as ulcers.

These combinations are commonly prescribed for conditions including:

  • Arthritis

  • Musculoskeletal pain

  • Gout

  • Menstrual cramps

  • Tendonitis

Common Brands

There are several common brands of NSAID / Histamine-2 Antagonist Combinations available in the market. Some of these include:

  • Arthotec

  • Preotact

  • Clinoril

  • Naprelan

  • Zorvolex

It is important to note that brand names may vary depending on the country and region. Consult with a healthcare professional regarding the specific brands available in your area.


While NSAID / Histamine-2 Antagonist Combinations can be effective in managing pain and reducing stomach acid production, it is crucial to be aware of potential side effects and follow safety precautions. Some important safety considerations include:

  • NSAIDs can increase the risk of gastrointestinal bleeding and cardiovascular events, so it is essential to use these medications at the lowest effective dose and for the shortest duration possible.

  • Patients with a history of gastrointestinal ulcers, bleeding disorders, heart conditions, kidney problems, or allergies to any of the components of the medication should use NSAID / Histamine-2 Antagonist Combinations with caution under medical supervision.

  • It is advisable to take these medications with food to help reduce the risk of stomach upset.

  • It is important to adhere to the prescribed dosage and not exceed the recommended duration of treatment to minimize the risk of side effects.

  • Prior to starting this medication, it is recommended to discuss potential drug interactions with a healthcare professional, especially if taking other medications.

Remember, the information provided here is for general knowledge purposes, and it is important to consult with a healthcare professional for personalized advice regarding your specific condition and treatment options.

List of NSAID / Histamine-2 Antagonist Combinations