HomeDrug ClassesNSAID / Prostaglandin Combinations

NSAID / Prostaglandin Combinations: Uses, Common Brands, and Safety Info

NSAID/Prostaglandin combinations are drugs that combine a nonsteroidal anti-inflammatory drug (NSAID) with a prostaglandin. They are used to manage pain and inflammation in conditions like arthritis. Common brands include Arthrotec, Duexis, and Prevacid NapraPAC. While they can have side effects like stomach upset, they may also increase the risk of cardiovascular events. It is important to follow dosage instructions and consult a healthcare provider.


NSAID/Prostaglandin combinations are a class of drugs that combine a nonsteroidal anti-inflammatory drug (NSAID) with a prostaglandin. This combination provides a dual mechanism of action, targeting inflammation and pain relief simultaneously. The NSAID component reduces inflammation and relieves pain, while the prostaglandin component helps protect the stomach lining from the damaging effects of the NSAID.


The NSAID/Prostaglandin combinations are primarily used to manage pain and inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis. These drugs can alleviate joint pain, stiffness, and swelling, allowing individuals to resume their daily activities with greater ease. Additionally, NSAID/Prostaglandin combinations are sometimes prescribed to prevent ulcer formation in patients who are at high risk of developing gastric ulcers when taking NSAIDs alone.

Common Brands

Several commonly prescribed brands of NSAID/Prostaglandin combinations include: 1. Arthrotec (diclofenac/misoprostol) 2. Duexis (ibuprofen/famotidine) 3. Prevacid NapraPAC (lansoprazole/naproxen sodium) These brands differ in terms of the specific medications and dosages used, but they all combine an NSAID with a prostaglandin to provide dual benefits.


When taking NSAID/Prostaglandin combinations, it is important to follow the recommended dosage and duration prescribed by your healthcare provider. These combinations can have potential side effects, similar to individual NSAIDs, which may include stomach upset, heartburn, nausea, and diarrhea. Taking these medications with food or milk can help reduce the risk of stomach-related side effects. However, it is important to note that NSAID/Prostaglandin combinations may increase the risk of serious cardiovascular events, including heart attack and stroke, especially when used at high doses or for prolonged periods. Individuals with a history of cardiovascular disease, high blood pressure, or other risk factors for heart disease should exercise caution when using these medications and consult their healthcare provider for proper guidance. It is crucial to inform your healthcare provider about any other medications you are taking, including over-the-counter drugs, as some medications may interact with NSAID/Prostaglandin combinations, potentially leading to adverse effects or reduced effectiveness. In summary, NSAID/Prostaglandin combinations are a class of drugs that provide dual benefits for pain relief and inflammation reduction. They are commonly used to manage conditions like osteoarthritis and rheumatoid arthritis while minimizing the risk of gastrointestinal ulcers. However, it is important to use these medications as directed and be aware of the potential side effects and interactions. Consulting with a healthcare provider is essential to ensure safe and effective use of these medications.

List of NSAID / Prostaglandin Combinations