HomeDrug ClassesNSAID / Proton Pump Inhibitor Combinations

NSAID / Proton Pump Inhibitor Combinations: Uses, Common Brands, and Safety Info

NSAID / PPI combinations are used to manage NSAID-induced gastric ulcers and GI complications. Common brands include Vimovo and Duexis. Safety considerations include possible side effects and drug interactions. It is essential to follow dosage instructions and consult a healthcare professional.


NSAID / Proton Pump Inhibitor (PPI) combinations are a class of drugs that are commonly used for the management of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers or other gastrointestinal (GI) complications. NSAIDs, such as ibuprofen or naproxen, are widely used for their pain-relieving and anti-inflammatory properties. However, long-term use of NSAIDs can cause irritation and damage to the stomach lining, leading to ulcers or other GI complications. PPIs, including omeprazole and esomeprazole, are commonly prescribed to reduce stomach acid production and promote healing of the gastric ulcers. When combined, NSAID / PPI combinations provide dual action by both reducing inflammation and protecting the stomach lining.

Common Brands

Several common brands of NSAID / PPI combinations are available in the market. Examples include: - Vimovo (esomeprazole/naproxen) - Duexis (famotidine/ibuprofen) - Prevacid NapraPAC (lansoprazole/naproxen) It is important to note that these brand names may vary depending on the country and region. It is recommended to consult with a healthcare professional or pharmacist to determine the availability and appropriate choice of NSAID / PPI combination based on individual needs.


As with any medication, the safety of NSAID / PPI combinations should be carefully considered. While these combinations can be highly effective in managing NSAID-induced gastric ulcers and GI complications, they are not without potential risks. It is essential to follow the prescribed dosage and duration as directed by a healthcare professional. NSAID / PPI combinations may cause side effects, which can vary depending on the specific drugs involved. Some common side effects include gastrointestinal upset (such as nausea, abdominal pain, or diarrhea), headaches, dizziness, or rash. If any concerning side effects occur, it is important to seek medical advice promptly. Individuals with a history of hypersensitivity or allergic reactions to NSAIDs, PPIs, or any of their components should avoid NSAID / PPI combinations. Additionally, caution should be exercised in patients with pre-existing medical conditions such as liver or kidney disease, bleeding disorders, or cardiovascular conditions. Drug interactions may occur if NSAID / PPI combinations are taken concomitantly with certain medications, including blood thinners or antiplatelet drugs. It is advisable to inform a healthcare professional about all medications being taken to avoid potential interactions. In conclusion, NSAID / PPI combinations are a class of drugs commonly used to treat NSAID-induced gastric ulcers and other GI complications. They provide dual action by reducing inflammation and protecting the stomach lining. However, like any medication, they have potential side effects and safety considerations. It is important to consult with a healthcare professional for proper guidance and to ensure the appropriate use of these combinations based on individual circumstances.

List of NSAID / Proton Pump Inhibitor Combinations