HomeDrug ClassesOpioid / Phenothiazine Combinations

Opioid / Phenothiazine Combinations: Uses, Common Brands, and Safety Info

Opioid/phenothiazine combinations are medications used for moderate to severe pain and mental health conditions. Common brands include Phenergan with Codeine and Compazine. Safety precautions must be taken due to the potential for addiction and side effects like sedation. It is important to use these combinations under medical guidance and avoid sharing them.

Opioid / Phenothiazine Combinations

Opioid / Phenothiazine combinations are a class of medications that include a combination of an opioid and a phenothiazine. This unique drug class is used to treat certain types of moderate to severe pain and may also be used for the management of mental health conditions.


The primary use of opioid / phenothiazine combinations is the relief of moderate to severe pain. These medications are commonly prescribed for pain management after surgical procedures, in cancer patients, or in individuals experiencing acute or chronic pain due to various medical conditions, such as arthritis or fibromyalgia.

In addition, the phenothiazine component of these combinations may provide additional benefits for the management of mental health conditions. Phenothiazines are known for their antipsychotic effects and are sometimes used in combination with opioids to help manage certain psychiatric symptoms, such as agitation, hallucinations, or delusions in individuals who are suffering from mental health disorders.

Common Brands

There are several common brands of opioid / phenothiazine combinations available on the market. Some of the widely recognized brands include:

  • Phenergan with Codeine

  • Promethazine with Codeine

  • Compazine

  • Dronabinol with Phenothiazines

  • Perphenazine and Opioid combinations

It is important to note that the availability of specific brands may vary depending on the country and local regulations.


When using opioid / phenothiazine combinations, safety precautions must be observed due to the potential risks associated with these medications.

First and foremost, it is crucial to use these medicines strictly under the guidance and prescription of a qualified healthcare professional. These combinations have the potential for abuse and addiction and should only be used as directed by a healthcare provider.

Additionally, individuals taking these medications should be aware of the possible side effects, which may include sedation, dizziness, constipation, respiratory depression, or allergic reactions. It is important to report any concerning symptoms to a healthcare provider promptly.

As with any medication, opioid / phenothiazine combinations may interact with other drugs, including alcohol or certain psychiatric medications. Therefore, it is vital to inform the prescribing doctor about all current medications, medical conditions, and allergies to ensure the safe use of these combinations.

Finally, due to the potential for addiction, these medications should not be shared or used by anyone other than the individual for whom they are prescribed.

Overall, opioid / phenothiazine combinations are valuable medications for the management of pain and certain mental health conditions. However, they should always be used with caution, under medical supervision, and in strict adherence to the prescribed dosage to minimize potential risks and maximize their therapeutic benefits.

List of Opioid / Phenothiazine Combinations