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Recombinant Human DNases: Uses, Common Brands, and Safety Info

"Recombinant Human DNases, such as Pulmozyme, are medications used to treat respiratory disorders by breaking down excess mucus in the airways. Commonly prescribed for cystic fibrosis, these drugs improve lung function and reduce infection risk. Safety precautions include following prescribed dosage, avoiding drug interactions, and not using them for acute breathing difficulties."


Recombinant Human DNases are a class of medications developed to treat respiratory disorders by reducing excessive mucus production and improving lung function. These drugs work by breaking down DNA present in the excess mucus, making it thinner and easier to clear from the airways. Recombinant Human DNases are designed to mimic the effects of naturally occurring enzymes and are used primarily in the treatment of cystic fibrosis (CF) and other chronic obstructive pulmonary diseases (COPD).


Recombinant Human DNases are most commonly prescribed for patients with cystic fibrosis, a genetic disorder that affects the lungs and digestive system. In CF patients, excessive production of thick and sticky mucus can obstruct the airways, leading to recurrent infections and difficulty breathing. By facilitating the breakdown of DNA within the mucus, these medications help to improve lung function, reduce the frequency of respiratory infections, and enhance overall quality of life.

In addition to CF, Recombinant Human DNases may also be used in the treatment of other chronic respiratory conditions characterized by excess mucus production, such as COPD and bronchiectasis. These conditions can cause similar symptoms of airway obstruction and impaired lung function, which can be alleviated with the use of these medications.

Common brands

One of the most commonly prescribed Recombinant Human DNases is Pulmozyme, which contains dornase alfa as the active ingredient. Pulmozyme is available in solution form for inhalation and is usually administered daily using a nebulizer. Other brands may also exist, so it's important to consult a healthcare professional for specific brand recommendations and availability in your region.


Recombinant Human DNases are generally safe and well-tolerated when used as directed. However, as with any medication, there are certain precautions and considerations to be aware of:

  • It is crucial to follow the prescribed dosage and administration instructions provided by your healthcare provider.

  • Inform your healthcare provider of any other medications or supplements you are taking to avoid potential drug interactions.

  • It is important to note that Recombinant Human DNases should not be used to treat sudden breathing difficulties or as a rescue medication during an acute exacerbation. These drugs are intended for long-term management and should be used on a regular basis as prescribed.

  • Serious side effects are rare, but if you experience any signs of an allergic reaction or worsening respiratory symptoms, seek immediate medical attention.

  • As with all prescription medications, discuss any concerns or questions with your healthcare provider before starting or stopping treatment with Recombinant Human DNases.

Overall, Recombinant Human DNases have proven to be valuable tools in managing chronic respiratory conditions characterized by excess mucus production. By promoting mucus clearance and improving lung function, these medications help to enhance the quality of life for patients with cystic fibrosis, COPD, and other related respiratory disorders.

List of Recombinant Human DNases