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RET Inhibitors: Uses, Common Brands, and Safety Info

"RET inhibitors are targeted therapy drugs used to treat RET-altered cancers. Common brands include Retevmo, Capmatinib, and BLU-667. They work by blocking the RET protein, slowing cancer growth. Side effects can include diarrhea, nausea, and high blood pressure."

RET Inhibitors

RET inhibitors are a class of targeted therapy drugs that specifically target and inhibit the activity of the RET (rearranged during transfection) protein. This protein plays a crucial role in cell growth and division, and when it is mutated or overexpressed, it can drive the growth and spread of certain types of cancer.


RET inhibitors are primarily used in the treatment of cancers that are driven by RET alterations, such as RET fusion-positive non-small cell lung cancer (NSCLC) and RET-mutant medullary thyroid cancer (MTC). These drugs work by blocking the signaling pathways that are activated by RET mutations, thereby slowing down the growth and division of cancer cells.

Common Brands

There are several brands of RET inhibitors available on the market. Some of the commonly prescribed ones include: - Retevmo (selpercatinib) - Capmatinib (Tabrecta) - BLU-667 (Pralsetinib) It is important to note that the availability of specific brands may vary depending on the country and healthcare system.


As with any medication, RET inhibitors can have potential side effects. Common side effects may include diarrhea, nausea, fatigue, high blood pressure, and changes in liver function. It is essential for patients to discuss any concerns or side effects with their healthcare provider. Since RET inhibitors are targeted therapies, they generally have a more specific mechanism of action compared to conventional chemotherapy drugs. This targeted approach may result in a more favorable side effect profile. However, individual response to treatment can vary, and some patients may experience more severe side effects. It is crucial for patients to adhere to their prescribed dosage and follow all recommendations provided by their healthcare team. Regular monitoring and follow-up appointments are typically required to assess the effectiveness of the treatment and manage any potential side effects. In conclusion, RET inhibitors are a promising class of targeted therapy drugs used in the treatment of RET-altered cancers. They can help slow down the growth and spread of cancer cells by specifically targeting the RET protein. As with any medication, it is essential to work closely with healthcare professionals to discuss the potential benefits and risks of RET inhibitors and to ensure safe and effective use.

List of RET Inhibitors