HomeDrug ClassesSGLT2 Inhibitor / Gliptin / Biguanide Combinations

SGLT2 Inhibitor / Gliptin / Biguanide Combinations: Uses, Common Brands, and Safety Info

SGLT2 Inhibitor / Gliptin / Biguanide combinations are effective in managing type 2 diabetes mellitus, lowering blood sugar levels through various mechanisms of action. Common brands include Xigduo XR, Synjardy, Qtern, Steglujan, and Segluromet. While generally safe, patients should be aware of potential side effects and precautions, such as urinary tract infections and ketoacidosis. Regular monitoring and adherence to treatment guidelines are essential for


SGLT2 Inhibitor / Gliptin / Biguanide combinations are a class of drugs used to manage type 2 diabetes mellitus. This combination therapy helps lower blood sugar levels through multiple mechanisms of action. SGLT2 inhibitors reduce blood sugar by blocking the reabsorption of glucose in the kidneys, while gliptins enhance insulin secretion and inhibit glucagon release. Biguanides improve insulin sensitivity and decrease glucose production in the liver. By combining these drugs, their effects are synergistic, leading to better glycemic control in patients with type 2 diabetes.

Common Brands

Some commonly prescribed SGLT2 Inhibitor / Gliptin / Biguanide combinations include: - Xigduo XR (dapagliflozin / metformin extended-release) - Synjardy (empagliflozin / metformin) - Qtern (dapagliflozin / saxagliptin) - Steglujan (ertugliflozin / sitagliptin) - Segluromet (ertugliflozin / metformin) These brands offer different combinations and dosages, allowing healthcare providers to tailor treatment to individual patient needs.


Like any medication, SGLT2 Inhibitor / Gliptin / Biguanide combinations have potential side effects and safety considerations. Common side effects may include urinary tract infections, yeast infections, nasopharyngitis, and gastrointestinal symptoms such as nausea, diarrhea, or abdominal pain. It is essential for patients to be aware of these potential side effects and promptly report any adverse reactions to their healthcare provider. While these combinations have shown overall efficacy and safety, certain precautions should be considered. Patients with severe renal impairment, hepatic impairment, or a history of hypersensitivity to any of the individual components of the combination should exercise caution or consult with their healthcare provider for alternative treatment options. It is also crucial to monitor renal function periodically, especially in elderly patients or those with pre-existing kidney disease. Additionally, patients should be educated about the increased risk of ketoacidosis associated with SGLT2 inhibitors and be advised to seek immediate medical attention if symptoms such as nausea, vomiting, abdominal pain, fatigue, or shortness of breath occur. As with any medication, it is important for patients to follow their healthcare provider's instructions and regularly monitor their blood sugar levels. SGLT2 Inhibitor / Gliptin / Biguanide combinations are typically prescribed as part of a comprehensive treatment plan that includes dietary modifications, regular exercise, and lifestyle changes to achieve optimal diabetes management. In conclusion, SGLT2 Inhibitor / Gliptin / Biguanide combinations are a valuable therapeutic option for patients with type 2 diabetes mellitus, offering multiple mechanisms of action to assist in achieving glycemic control. With proper monitoring, adherence to treatment guidelines, and regular follow-up with healthcare providers, these combinations can help improve the quality of life for individuals living with type 2 diabetes.

List of SGLT2 Inhibitor / Gliptin / Biguanide Combinations