Tryptophan Hydroxylase Inhibitor: Uses, Common Brands, and Safety Info
Tryptophan hydroxylase inhibitors are drugs that inhibit an enzyme responsible for serotonin production. They are commonly used to treat carcinoid syndrome, with Xermelo being a well-known brand. Safety precautions and potential side effects should be considered when using these medications.
Description
Tryptophan hydroxylase inhibitor is a drug class that works by inhibiting the enzyme tryptophan hydroxylase. This enzyme is responsible for the conversion of tryptophan into serotonin, a neurotransmitter involved in regulating mood, appetite, and sleep. By inhibiting tryptophan hydroxylase, these drugs can regulate the levels of serotonin in the brain, offering potential therapeutic benefits for various conditions.
Uses
Tryptophan hydroxylase inhibitors are primarily used in the treatment of carcinoid syndrome, a condition characterized by the overproduction of serotonin by neuroendocrine tumors. The excessive serotonin release can cause symptoms such as diarrhea, flushing, and wheezing. By inhibiting tryptophan hydroxylase, these drugs help reduce the production of serotonin and alleviate the symptoms associated with carcinoid syndrome.
Common Brands
One widely used tryptophan hydroxylase inhibitor is Xermelo. Xermelo, or telotristat ethyl, is available as a tablet and is specifically approved for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog therapy in adults inadequately controlled by the somatostatin analog alone.
Safety
When using tryptophan hydroxylase inhibitors, it is essential to follow the prescribed dosage and instructions provided by your healthcare provider. Common side effects of these medications may include nausea, fatigue, headache, and flatulence. It is important to inform your doctor about any pre-existing medical conditions, current medications, or allergies before starting treatment with a tryptophan hydroxylase inhibitor.
Tryptophan hydroxylase inhibitors may interact with certain medications, such as those used to treat mental health disorders or high blood pressure. Therefore, it is crucial to inform your doctor about all medications you are taking to avoid potential drug interactions.
Always consult with a healthcare professional or pharmacist for personalized advice and to determine if a tryptophan hydroxylase inhibitor is suitable for your specific condition.