HomeDrug ClassesTypical Antipsychotic / Tricyclic Antidepressant Combinations

Typical Antipsychotic / Tricyclic Antidepressant Combinations: Uses, Common Brands, and Safety Info

Typical antipsychotic/tricyclic antidepressant combinations are medications used to treat conditions with symptoms of both psychosis and depression. Common brands include Symbyax, Imipraminox, and Trimipraminox. Proper medical supervision is necessary, as these combinations can have potent effects and may cause side effects such as drowsiness and weight gain. It is crucial to report any concerning side effects and inform healthcare providers about other medications and substances being used to avoid interactions.


Typical antipsychotic/tricyclic antidepressant combinations are a class of medications that combine drugs from the typical antipsychotic class and the tricyclic antidepressant class. These combinations are prescribed to treat certain conditions where symptoms of both psychosis and depression are present. By combining the effects of both drug classes, these combinations aim to provide a more comprehensive treatment approach for individuals with complex mental health conditions.


Typical antipsychotic/tricyclic antidepressant combinations are primarily used to manage conditions such as schizophrenia, bipolar disorder with psychotic features, and treatment-resistant depression. These combinations are typically prescribed when other medications have been ineffective in alleviating symptoms or when a patient's condition requires a more complex treatment approach.

Common Brands

Some common brands of typical antipsychotic/tricyclic antidepressant combinations include: 1. Symbyax: This combination medication contains the typical antipsychotic drug olanzapine and the tricyclic antidepressant fluoxetine. It is primarily used to treat bipolar disorder with depressive episodes. 2. Imipraminox: This combination includes the typical antipsychotic drug imipramine and the tricyclic antidepressant doxepin. It is used to treat treatment-resistant depression and psychosis associated with mood disorders. 3. Trimipraminox: This combination consists of the typical antipsychotic drug trimipramine and the tricyclic antidepressant imipramine. It is prescribed for individuals with severe depressive symptoms accompanied by psychosis. It is important to note that the availability of specific brands may vary based on the country and region.


Typical antipsychotic/tricyclic antidepressant combinations should only be used under the guidance and supervision of a qualified healthcare professional. These combinations often involve medications with potent effects and may have specific safety considerations. As with any medication, it is important for individuals using typical antipsychotic/tricyclic antidepressant combinations to adhere to the prescribed dosage and schedule. Abruptly stopping these medications without proper medical supervision can lead to withdrawal symptoms or a sudden worsening of the underlying condition. Like other antipsychotic and antidepressant medications, typical antipsychotic/tricyclic antidepressant combinations may also cause a range of side effects. These can include drowsiness, dry mouth, dizziness, blurred vision, changes in blood pressure, weight gain, and sexual dysfunction. It is essential to report any concerning side effects to a healthcare professional promptly. Additionally, these combinations may interact with other medications or substances, such as alcohol or certain drugs metabolized by the liver. It is crucial to inform healthcare providers about all current medications, supplements, and substances being used to avoid potential interactions and adverse effects. In conclusion, typical antipsychotic/tricyclic antidepressant combinations are prescribed to address complex mental health conditions characterized by both psychosis and depression. While they may offer benefits in certain cases, the use of these combinations should be carefully monitored by healthcare professionals and individualized to each patient's needs.

List of Typical Antipsychotic / Tricyclic Antidepressant Combinations