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VMAT2 Inhibitors: Uses, Common Brands, and Safety Info

VMAT2 inhibitors are drugs that work by inhibiting the VMAT2 protein, reducing the release of certain neurotransmitters. They are used to treat conditions such as Parkinson's disease, tardive dyskinesia, and hyperkinetic movement disorders. Common brands include Austedo and Ingrezza. It is important to use them under medical supervision and be aware of potential side effects and interactions.


VMAT2 inhibitors are a class of drugs that work by targeting and inhibiting the vesicular monoamine transporter type 2 (VMAT2) protein. This protein is responsible for transporting dopamine, norepinephrine, serotonin, and other monoamines into synaptic vesicles, which are then released into the synaptic cleft. By inhibiting VMAT2, these drugs decrease the release of these neurotransmitters, leading to therapeutic effects in various conditions. VMAT2 inhibitors play a crucial role in the treatment of several conditions, including Parkinson's disease, tardive dyskinesia, and hyperkinetic movement disorders.


VMAT2 inhibitors are primarily used in the management of Parkinson's disease. Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms such as tremors, rigidity, and bradykinesia. VMAT2 inhibitors, such as deutetrabenazine and valbenazine, can help control the involuntary movements associated with Parkinson's disease by reducing the amount of dopamine available for release in the synaptic cleft. In addition to Parkinson's disease, VMAT2 inhibitors are also utilized in the treatment of tardive dyskinesia. Tardive dyskinesia is a condition that occurs as a result of long-term use of antipsychotic medications, primarily those that affect dopamine receptors. The prolonged exposure to these medications can lead to abnormal, involuntary movements, such as repetitive facial grimacing and tongue protrusion. VMAT2 inhibitors can help alleviate the symptoms of tardive dyskinesia by modulating the release of dopamine and other neurotransmitters. Furthermore, VMAT2 inhibitors have shown potential in managing hyperkinetic movement disorders, including Huntington's disease and Tourette's syndrome. These disorders are characterized by the presence of uncontrollable movements or tics. By regulating the release of neurotransmitters involved in these conditions, VMAT2 inhibitors can help reduce motor symptoms, providing relief to the affected individuals.

Common Brands

Some common brands of VMAT2 inhibitors include: 1. Deutetrabenazine (brand name: Austedo): It is FDA-approved for the treatment of chorea associated with Huntington's disease and tardive dyskinesia. 2. Valbenazine (brand name: Ingrezza): It is primarily indicated for the treatment of tardive dyskinesia. It is important to note that these are just a few examples of VMAT2 inhibitors, and there may be other brands available in different regions.


VMAT2 inhibitors should be used under the supervision of a healthcare professional. Like any medication, they may have potential side effects, interactions, and contraindications. Common side effects may include drowsiness, fatigue, nausea, and constipation. It is essential to discuss any pre-existing medical conditions, current medications, or allergies with a healthcare provider before starting VMAT2 inhibitors. As with any medication, it is crucial to follow the prescribed dosage and not exceed it without medical guidance. Abruptly stopping the use of VMAT2 inhibitors can lead to a worsening of symptoms, especially in Parkinson's disease. Therefore, it is important to consult a healthcare professional before making any adjustments to the treatment regimen. In summary, VMAT2 inhibitors are a class of drugs used in the treatment of Parkinson's disease, tardive dyskinesia, and hyperkinetic movement disorders. They work by inhibiting VMAT2, thereby regulating the release of neurotransmitters involved in these conditions. While they can be beneficial, it is important to use them cautiously and adhere to the guidance of a healthcare professional to ensure safety and optimal therapeutic outcomes.