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This document outlines essential safety information and warnings regarding the use of darifenacin. Please read the following carefully and discuss any concerns you may have with your healthcare provider.

• Angioedema Risk: Darifenacin may cause a rare but serious condition called angioedema, characterized by swelling of the face, lips, tongue, or throat, which may lead to breathing difficulties. This reaction can occur even after the first dose.

• Nervous System Side Effects: The medication may induce sleepiness, dizziness, headaches, confusion, or, in rare cases, hallucinations. Monitor your response to the medication, especially when starting or adjusting the dose. Exercise caution if you are taking other drugs that affect the nervous system.

• Urinary Issues: Darifenacin can exacerbate urination difficulties. Inform your healthcare provider if you have existing urinary problems, such as benign prostatic hyperplasia (BPH), to determine the suitability of this medication for you.

• Digestive Concerns: This medication can slow gastrointestinal movement and worsen certain digestive conditions. Consult your healthcare provider if you have severe constipation, ulcerative colitis, or myasthenia gravis. Darifenacin is contraindicated for individuals with intestinal blockages.

• Glaucoma Considerations: If you have glaucoma, particularly narrow-angle glaucoma, discuss the potential risks and benefits of darifenacin with your healthcare provider, as it may worsen certain types of glaucoma.

Contraindications:

• Do not use darifenacin if you have uncontrolled narrow-angle glaucoma.
• Avoid if you are unable to urinate or fully empty your bladder (urinary retention).
• The medication is contraindicated in cases of gastric or intestinal blockages.

If you experience any adverse effects or symptoms of overdose, seek immediate medical attention. Your healthcare provider is your best resource for managing any potential risks associated with this medication.

When taking this medication, it's important to be aware of potential side effects. Commonly, users may experience dry mouth, constipation, and occasionally urinary tract infections. These effects are generally mild, but if they persist, consider consulting a healthcare provider. To ease dry mouth, try sugarless candy or gum, ice chips, or increase water intake. Dietary fiber, hydration, and exercise can help mitigate constipation.

Other side effects include indigestion, stomach pain, nausea, diarrhea, dizziness, weakness, headache, dry skin, dry eyes, blurry vision, flu-like symptoms, swelling, and weight gain. These are generally not severe but should be monitored. If any of these symptoms worsen, seek guidance from a healthcare professional.

Serious side effects, though rare, demand immediate medical attention. These include severe allergic reactions such as angioedema, indicated by swelling of the face, lips, tongue, or throat and breathing difficulties. Additionally, severe stomach or abdominal pain, prolonged constipation, difficulty urinating, signs of kidney infection, or mental changes like confusion or hallucinations should be addressed urgently. If you experience eye pain, swelling, redness, or vision changes, seek prompt medical assistance. Always communicate any unusual symptoms to your healthcare provider.

When taking Darifenacin, it's important to be aware of potential drug interactions. Inform your healthcare provider about all medications and supplements you're using, whether they are prescribed, over-the-counter, vitamins, or herbal products.

Certain drugs should not be used with Darifenacin, such as potassium supplements, as this combination is generally not recommended. Your doctor might choose a different treatment or adjust your current medications.

Some medications may still be used with Darifenacin, but caution is advised. These include Amifampridine, Bupropion, Ceritinib, Clozapine, Conivaptan, Desipramine, Donepezil, Duvelisib, Flecainide, Fosnetupitant, Glucagon, Glycopyrrolate, Glycopyrronium Tosylate, Idelalisib, Imipramine, Itraconazole, Ivosidenib, Larotrectinib, Lefamulin, Lorlatinib, Lumacaftor, Methacholine, Netupitant, Quetiapine, Revefenacin, Scopolamine, Secretin Human, Thioridazine, and Tiotropium. Your doctor may need to adjust the dosage or frequency of these medications if they must be taken together.

Additionally, using Darifenacin with Ketoconazole might increase the risk of side effects, but it may be necessary for effective treatment. Your healthcare provider will manage the dosages accordingly to ensure safe use.