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The safety and warning information below provides essential guidance on the use of solifenacin (Vesicare). It highlights potential risks, necessary precautions, and specific instructions for various populations. Please read carefully and consult your healthcare provider if you have questions or concerns.

• Angioedema Risk: Solifenacin can cause angioedema, a serious condition involving swelling of the face, throat, tongue, or eyes, which may lead to breathing difficulties. Seek emergency medical assistance immediately if you experience sudden breathing problems or facial swelling.

• Nervous System Side Effects: This medication may induce sleepiness, dizziness, headaches, confusion, or hallucinations. It's important to be cautious when starting the medication or adjusting the dose. Avoid driving or engaging in activities requiring full attention until you know how the drug affects you. Inform your healthcare provider if these side effects disrupt your daily life. Be especially cautious if you are taking other medications with similar nervous system effects.

• Digestive System Precautions: Solifenacin is generally not recommended for individuals with conditions that slow gut movement. Those with intestinal blockages should not use this medication, as it can exacerbate digestive issues.

• Glaucoma Considerations: If you have glaucoma, discuss the risks and benefits of solifenacin with your healthcare provider. It may worsen certain types of glaucoma.

• QT Prolongation Warning: At doses higher than recommended, solifenacin may lead to QT prolongation, a heart rhythm disorder. Symptoms such as chest pain, pounding heart, shortness of breath, or lightheadedness require immediate medical attention. Those with a history of QT prolongation or who are on other medications affecting heart rhythm should exercise caution.

Contraindications: Solifenacin should not be used if you have the following conditions, as it may lead to serious health risks:

• Uncontrolled narrow-angle glaucoma
• Inability to urinate or fully empty the bladder, often associated with prostate issues
• Stomach or intestinal blockage

Always consult your healthcare provider before starting solifenacin, especially if you have existing health conditions or are taking other medications.

When taking this medication, some common side effects may include dry mouth, constipation, drowsiness, stomach upset, blurred vision, dry eyes, headache, and unusual tiredness or weakness. These effects are generally mild and manageable. For instance, to alleviate dry mouth, you can suck on sugarless candy, chew gum, or drink water. To help prevent constipation, consider increasing your dietary fiber intake, staying hydrated, and exercising regularly.

While many people do not experience serious side effects, it is important to be aware of them. Contact your healthcare provider if you experience severe stomach or abdominal pain, persistent constipation for more than three days, or difficulty urinating. Additionally, signs of a kidney infection like painful or frequent urination, fever, or bloody urine, as well as mental changes such as confusion or hallucinations, should be reported promptly.

In very rare cases, serious side effects like eye pain, vision changes, or an allergic reaction characterized by rash, swelling, or breathing difficulties may occur. Immediate medical attention is crucial if these symptoms arise. Rare but serious conditions such as angioedema or abnormal heart rhythms also require urgent care. Always consult your healthcare provider if you encounter any side effects not listed here.

Solifenacin (Vesicare) can interact with various medications, which may impact its effectiveness or increase the risk of side effects. It is important to inform your healthcare provider about any other drugs you are using, including prescription, over-the-counter medications, vitamins, and herbal supplements. Some drugs, such as pramlintide and potassium tablets or capsules, may interact with solifenacin.

Certain medications can influence how solifenacin is processed in your body. For instance, azole antifungals like itraconazole and ketoconazole, as well as mifepristone, can affect solifenacin's removal from your system, which may alter its efficacy.

There are specific medications that should generally not be used in conjunction with solifenacin. These include Bepridil, Cisapride, Dronedarone, Fluconazole, Mesoridazine, Nelfinavir, Pimozide, Piperaquine, Posaconazole, Saquinavir, Sparfloxacin, Terfenadine, Thioridazine, and Ziprasidone. In some cases, your doctor might need to adjust your treatment plan if these medications are required.

Additionally, there is a wide range of medications that are usually not recommended with solifenacin but might be necessary in certain situations. If prescribed together, your healthcare provider may adjust the dosage or frequency of the medications. Some examples include Alfuzosin, Amiodarone, Amitriptyline, Azithromycin, Bupropion, Ciprofloxacin, Fluoxetine, Haloperidol, Methadone, Quetiapine, Sertraline, and many others. Always consult with your doctor or pharmacist for guidance tailored to your specific health needs.