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Estazolam, a medication used for sleep disorders, carries several safety warnings and precautions that must be carefully considered to minimize risks. It is essential to understand these risks and discuss any concerns with your healthcare provider.

• Risk of Abuse and Dependence: Estazolam may lead to misuse and addiction, which can increase the likelihood of overdose and potentially result in death. The risk is heightened when taken in higher doses or over extended periods. It is important to adhere strictly to the prescribed dosage and duration.

• Interactions with Other Substances: Combining estazolam with alcohol, opioids, or other medications that cause drowsiness or breathing difficulties can lead to severe side effects, including extreme drowsiness, breathing problems, and even death. Consult your doctor if you must take opioids to ensure safe use or explore alternative treatments.

• Withdrawal Symptoms: Abruptly discontinuing estazolam, especially after long-term use or high doses, can cause serious withdrawal symptoms such as headaches, restlessness, confusion, depression, nausea, or seizures. To prevent these symptoms, your doctor may gradually reduce your dosage.

• Effect on Alertness: This medication can cause drowsiness and impair concentration and focus. Avoid activities requiring alertness, such as driving or operating heavy machinery, until you know how estazolam affects you. Alcohol and other drowsiness-inducing drugs can intensify these effects.

• Severe Allergic Reactions: Some individuals may experience allergic reactions to estazolam, including itching, fever, nausea, difficulty breathing, or a rapid heartbeat. Seek immediate medical attention if you notice signs of anaphylaxis such as hives, facial swelling, or throat tightness.

• Abnormal Sleep Behaviors: Estazolam can cause unusual behaviors during sleep, such as sleepwalking or sleep driving, particularly if taken with alcohol or other sedatives. If this occurs, consult your doctor as an alternative medication may be more suitable.

• Mental Health Concerns: The medication may provoke suicidal thoughts or behaviors, especially in individuals with a history of depression. Seek immediate medical help if you or others observe significant changes in mood or behavior.

• Specific Contraindications: Do not use estazolam if you are taking antifungal medications like ketoconazole or itraconazole due to potential severe interactions.

In case of an overdose or severe side effects, seek immediate medical assistance. Always take estazolam as directed by your healthcare provider to minimize risks and ensure safe use.

Common side effects:

• Sleepiness
• Headaches
• Weakness
• Slow muscle movements
• Dizziness
• Nervousness
• General discomfort

Less common but important to monitor:

• Pain
• Poor coordination
• Muscle stiffness
• Confusion
• Depression
• Abnormal thoughts or dreams
• Nausea
• Indigestion
• Itchiness
• Cold symptoms

Serious side effects:

• Slowed brain activity
• Excessive sleepiness
• Coma
• Trouble breathing
• Dangerous sleep behaviors (e.g., sleepwalking, sleep-driving)
• Serious allergic reaction
• Thoughts of suicide
• Severe mood changes

Interactions with high risk of serious adverse effects and should be avoided:

• Flumazenil
• Sodium Oxybate

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Alfentanil
• Alprazolam
• Amobarbital
• Codeine
• Fentanyl
• Gabapentin
• Hydrocodone
• Ketamine
• Methadone
• Morphine
• Oxycodone
• Tramadol
• Zolpidem
• Ribociclib
• Itraconazole
• Ketoconazole
• Rifapentine
• St John's Wort
• Theophylline

Interactions with low risk that usually do not require a change in therapy:

• Cetirizine
• Carisoprodol
• Cyclobenzaprine
• Diphenhydramine
• Lorazepam