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When considering the use of Folplex 2.2, it's important to be aware of certain safety precautions to ensure its appropriate use:

• Allergic Reactions: Individuals with known allergies to folic acid, vitamin B12, vitamin B6, or any other components of Folplex 2.2 should avoid using this supplement.

• Pernicious Anemia: Folic acid doses above 0.1 mg daily may mask the symptoms of pernicious anemia, a condition where the body can't absorb vitamin B12 properly. This can lead to a temporary improvement in blood tests while neurological damage continues to progress. Therefore, it's crucial to have a proper diagnosis and consult a healthcare provider before starting Folplex 2.2.

• Pediatric Use: The safety and effectiveness of Folplex 2.2 in children have not been established. Parents and caregivers should consult a pediatrician before administering this supplement to children.

• Accidental Overdose: As with all medications, keep Folplex 2.2 out of reach of children. In case of accidental overdose, seek immediate medical assistance or contact a poison control center.

Always consult with a healthcare professional before starting any new supplement to ensure it aligns with your individual health needs and conditions.

When taking Folplex 2.2, it's important to be aware of potential interactions with other medications:

• Capecitabine: Combining Folplex 2.2 with capecitabine may enhance the effects of capecitabine, increasing the risk of serious side effects such as anemia, bleeding problems, infections, and nerve damage. Symptoms to watch for include severe nausea and vomiting, diarrhea, unusual fatigue, dizziness, fainting, unusual bleeding or bruising, blood in the stools, fever, chills, body aches, flu-like symptoms, skin reactions, mouth ulcers or sores, and numbness, burning, or tingling in the hands and feet. Consult your doctor if you experience any of these symptoms.

• Maralixibat: This medication may reduce the absorption of fat-soluble vitamins such as A, D, E, and K. Regular blood tests are recommended during treatment to ensure adequate vitamin levels and to determine if any adjustments to your vitamin supplements are necessary.

• Pafolacianine: Using Folplex 2.2 with pafolacianine may decrease the effectiveness of pafolacianine in detecting cancer tissue. It may be necessary to stop taking Folplex 2.2 48 hours before receiving pafolacianine.

• Levodopa: Folplex 2.2 may interact with levodopa, potentially affecting its efficacy. Consult your doctor for guidance if you are taking levodopa.

• Altretamine and Cisplatin: These medications may have serious interactions with Folplex 2.2. Inform your doctor if you are using these drugs.

• Folic Acid Antagonists (e.g., Methotrexate), Hydantoins (e.g., Phenytoin), and Pyrimethamine: Folplex 2.2 may interact with these medications. Discuss with your doctor if you are taking any of these drugs.

Always inform your healthcare provider about all medications, vitamins, and herbal supplements you are taking to avoid potential interactions.