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When taking this medication, you may experience some mild side effects such as dry mouth, mild stomach upset, trouble sleeping, dizziness, headache, nervousness, loss of appetite, or increased thirst. These are generally manageable, but if they persist or worsen, it's important to consult a healthcare professional. While many individuals using this medicine don’t experience serious side effects, it's crucial to be aware of them. Serious side effects that require immediate medical attention include fast or irregular heartbeat, uncontrolled shaking or tremors, mental or mood changes like confusion, and difficulty urinating.

In rare cases, a very severe side effect such as seizures can occur, necessitating urgent medical help. Additionally, although a severe allergic reaction to this medication is uncommon, you should seek immediate medical assistance if you notice symptoms such as a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing.

Remember, this is not an exhaustive list of potential side effects. If you experience any other unusual symptoms, contacting a healthcare provider is advisable. The benefits of the medication are considered to outweigh the risks for most patients, which is why many continue to use it with minimal issues.

Avoid taking MAO inhibitors while using this medication, as this can result in a severe, potentially life-threatening interaction. MAO inhibitors include drugs like isocarboxazid, linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine. Most MAO inhibitors should also be avoided for two weeks before starting this treatment. Consult your doctor about the appropriate timing for starting or stopping this medication.

Be sure to check all your medication labels, especially those for cough and cold remedies, as they might contain similar ingredients like decongestants such as phenylephrine. Consult your pharmacist to ensure safe use of these products.

Loratadine is closely related to Desloratadine, so do not take any products containing desloratadine while on loratadine.

Additionally, this medication might affect certain lab tests, such as allergy skin tests, by causing inaccurate results. Inform all your healthcare providers and lab personnel that you are taking this medication to avoid any issues.