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This communication outlines critical safety information and warnings regarding the use of ganirelix (Fyremadel). It is important to review these details and discuss any concerns with your healthcare provider.

• Allergic Reactions: Some individuals may experience severe allergic reactions, including anaphylaxis, which can be life-threatening and involve symptoms such as hives, rash, swelling of the lips or tongue, or difficulty breathing. If these occur, seek medical assistance immediately. Additionally, individuals with a latex allergy should exercise caution, as there is a risk associated with this medication.

• Pregnancy Risks: Ganirelix (Fyremadel) is contraindicated during pregnancy due to the potential for harm to the unborn child. It is advised to undergo a pregnancy test before starting treatment to ensure you are not pregnant. Notify your fertility specialist immediately if pregnancy occurs during treatment.

In certain situations, ganirelix (Fyremadel) should not be used due to significant health risks. These include:

• Having a known allergy to latex or dry natural rubber.
• Being allergic to GnRH agonists, such as leuprolide.
• Being currently pregnant or suspecting pregnancy.

If any of these conditions apply to you, it is crucial to consult with your healthcare provider before commencing treatment with ganirelix (Fyremadel).

When taking this medication, some individuals may experience common side effects such as redness or pain at the injection site, headache, mild nausea, stomach pain, or tiredness. These effects are generally mild and tend to resolve on their own, but if they persist or worsen, it’s important to consult with a healthcare provider. Uncommon side effects, like unusual vaginal bleeding, should also be reported to a healthcare provider for further advice.

A more serious condition associated with this medication is ovarian hyperstimulation syndrome (OHSS), which can occur during or after treatment. In rare cases, OHSS can lead to severe symptoms such as fluid accumulation in the abdomen, chest, and heart area, severe abdominal pain, nausea, sudden weight gain, or decreased urination. Immediate medical attention is necessary if any of these symptoms arise.

Additionally, although very rare, serious allergic reactions may occur. Symptoms such as a rash, itching, swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing require urgent medical care. While not exhaustive, this list covers the primary side effects of the medication; any other unexpected effects should be discussed with a healthcare provider.